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Histamine H3 ligands: just pharmacological tools or potential therapeutic agents? Hendrik Timmerman pp 4 - 11; DOI: 10.1021/jm00163a001 |
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.alpha.-Diketone and .alpha.-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases Michael R. Angelastro, Shujaath Mehdi, Joseph P. Burkhart, Norton P. Peet, and Philippe Bey pp 11 - 13; DOI: 10.1021/jm00163a002 |
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Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists Arthur A. Nagel, Terry Rosen, James Rizzi, June Daffeh, Karen Guarino, Jolanta Nowakowski, Lawrence A. Vincent, James Heym, Stafford McLean, and et al. pp 13 - 16; DOI: 10.1021/jm00163a003 |
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Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides Robert Vince and Mei Hua pp 17 - 21; DOI: 10.1021/jm00163a004 |
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Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus Bruce D. Roth, D. F. Ortwine, M. L. Hoefle, C. D. Stratton, D. R. Sliskovic, M. W. Wilson, and R. S. Newton pp 21 - 31; DOI: 10.1021/jm00163a005 |
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Inhibitors of cholesterol biosynthesis. 2. 1,3,5-Trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles D. R. Sliskovic, B. D. Roth, M. W. Wilson, M. L. Hoefle, and R. S. Newton pp 31 - 38; DOI: 10.1021/jm00163a006 |
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Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain Yigong Gao, Vishnu J. Ram, Alexander Campbell, Nora S. Kula, Ross J. Baldessarini, and John L. Neumeyer pp 39 - 44; DOI: 10.1021/jm00163a007 |
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Synthesis, structure, and antiparasitic activity of sulfamoyl derivatives of ribavirin Ganesh D. Kini, Elizabeth M. Henry, Roland K. Robins, Steven B. Larson, J. Joseph Marr, Randolph L. Berens, Cyrus J. Bacchi, Henry C. Nathan, and Jan S. Keithly pp 44 - 48; DOI: 10.1021/jm00163a008 |
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5-[(Aminoalkyl)amino]imidazo[4,5,1-de]acridin-6-ones as a novel class of antineoplastic agents. Synthesis and biological activity Wieslaw M. Cholody, Sante Martelli, Jolanta Paradziej-Lukowicz, and Jerzy Konopa pp 49 - 52; DOI: 10.1021/jm00163a009 |
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Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids G. Beck, K. Kesseler, E. Baader, W. Bartmann, A. Bergmann, E. Granzer, H. Jendralla, B. Von Kerekjarto, R. Krause, and et al. pp 52 - 60; DOI: 10.1021/jm00163a010 |
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Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids H. Jendralla, E. Baader, W. Bartmann, G. Beck, A. Bergmann, E. Granzer, B. Von Kerekjarto, K. Kesseler, R. Krause, and et al. pp 61 - 70; DOI: 10.1021/jm00163a011 |
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GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-.beta.-proline Lone Nielsen, Lotte Brehm, and Povl Krogsgaard-Larsen pp 71 - 77; DOI: 10.1021/jm00163a012 |
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Cephalosporin 3'-quinolone esters with a dual mode of action Harry A. Albrecht, George Beskid, Ka Kong Chan, James G. Christenson, Roy Cleeland, Kenneth H. Deitcher, Nafsika H. Georgopapadakou, Dennis D. Keith, David L. Pruess, and et al. pp 77 - 86; DOI: 10.1021/jm00163a013 |
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New leupeptin analogs: synthesis and inhibition data Rose M. McConnell, George E. Barnes, Charles F. Hoyng, and J. Martin Gunn pp 86 - 93; DOI: 10.1021/jm00163a014 |
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DNA intercalating properties of tetrahydro-9-aminoacridines. Synthesis and sodium-23 NMR spin-lattice relaxation time measurements Joergen Dinesen, Jens Peter Jacobsen, Frede P. Hansen, Erik B. Pedersen, and Hanne Eggert pp 93 - 97; DOI: 10.1021/jm00163a015 |
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Cyclization-activated prodrugs. Basic carbamates of 4-hydroxyanisole Walfred S. Saari, John E. Schwering, Paulette A. Lyle, Steven J. Smith, and Edward L. Engelhardt pp 97 - 101; DOI: 10.1021/jm00163a016 |
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Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors Pui Kai Li and Robert W. Brueggemeier pp 101 - 105; DOI: 10.1021/jm00163a017 |
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cis-Diamineplatinum(II) complexes containing phosphono carboxylate ligands as antitumor agents L. Steven Hollis, Arthur V. Miller, Alan R. Amundsen, John E. Schurig, and Eric W. Stern pp 105 - 111; DOI: 10.1021/jm00163a018 |
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Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines Brian D. Palmer, William R. Wilson, Susan M. Pullen, and William A. Denny pp 112 - 121; DOI: 10.1021/jm00163a019 |
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Synthesis and in vivo antitumor activity of 2-amino-9H-purine-6-sulfenamide, -sulfinamide, and -sulfonamide and related purine ribonucleosides Ganapathi R. Revankar, Naeem B. Hanna, Nobutaka Imamura, Arthur F. Lewis, Steven B. Larson, Rick A. Finch, Thomas L. Avery, and Roland K. Robins pp 121 - 128; DOI: 10.1021/jm00163a020 |
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A novel, nonsteroidal inhibitor of androgen binding to the rat androgen binding protein: diethyl [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl]amino]methylene]propanedioate Richard C. Winneker, Margaret M. Wagner, and Baldev Singh pp 129 - 132; DOI: 10.1021/jm00163a021 |
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Anticandidal properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid oligopeptides Ryszard Andruszkiewicz, Slawomir Milewski, Teresa Zieniawa, and Edward Borowski pp 132 - 135; DOI: 10.1021/jm00163a022 |
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Structure-activity relationships of antifilarial antimycin analogs: a multivariate pattern recognition study David L. Selwood, David J. Livingstone, John C. W. Comley, Alan B. O'Dowd, Alan T. Hudson, Peter Jackson, Karamjit S. Jandu, Valerie S. Rose, and Jeremy N. Stables pp 136 - 142; DOI: 10.1021/jm00163a023 |
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Synthesis and structure-activity relationships of new 7-[3-(fluoromethyl)piperazinyl]- and -(fluorohomopiperazinyl)quinolone antibacterials Carl B. Ziegler, P. Bitha, N. A. Kuck, T. J. Fenton, P. J. Petersen, and Y. I. Lin pp 142 - 146; DOI: 10.1021/jm00163a024 |
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Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines Michael E. Bembenek, Creed W. Abell, Linda A. Chrisey, Maria D. Rozwadowska, Wieslaw Gessner, and Arnold Brossi pp 147 - 152; DOI: 10.1021/jm00163a025 |
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Indolo[2,1-a]isoquinolines. Syntheses, steroid hormone receptor binding affinities, and cytostatic activity Reinhard Ambros, Martin R. Schneider, and Silvia Von Angerer pp 153 - 160; DOI: 10.1021/jm00163a026 |
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Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones James F. Wolfe, Terry L. Rathman, Mark C. Sleevi, James A. Campbell, and Thomas D. Greenwood pp 161 - 166; DOI: 10.1021/jm00163a027 |
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Structure-activity relationship of anthracyclines in vitro D. Hoffmann, H. G. Berscheid, D. Boettger, P. Hermentin, H. H. Sedlacek, and H. P. Kraemer pp 166 - 171; DOI: 10.1021/jm00163a028 |
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Synthesis and characterization of iodobenzamide analogs: potential D-2 dopamine receptor imaging agents Raymond A. Murphy, Hank F. Kung, Mei Ping Kung, and Jeffrey Billings pp 171 - 178; DOI: 10.1021/jm00163a029 |
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil Alan D. Borthwick, Derek N. Evans, Barrie E. Kirk, Keith Biggadike, Anne M. Exall, Peter Youds, Stanley M. Roberts, David J. Knight, and Jonathan A. V. Coates pp 179 - 186; DOI: 10.1021/jm00163a030 |
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Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]purines Michael R. Harnden, Paul G. Wyatt, Malcolm R. Boyd, and David Sutton pp 187 - 196; DOI: 10.1021/jm00163a031 |
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Benzodiazepine receptor binding activity of 8-substituted-9-(3-substituted-benzyl)-6-(dimethylamino)-9H-purines James L. Kelley, Ed W. McLean, James A. Linn, Mark P. Krochmal, Robert M. Ferris, and James L. Howard pp 196 - 202; DOI: 10.1021/jm00163a032 |
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Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases Catherine Hildebrand, Daniele Sandoli, Federico Focher, Joseph Gambino, Giovanni Ciarrocchi, Silvio Spadari, and George Wright pp 203 - 206; DOI: 10.1021/jm00163a033 |
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Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogs Hiroshi Yoshino, Takahiro Nakazawa, Yoshihiro Arakawa, Takeru Kaneko, Yutaka Tsuchiya, Manabu Matsunaga, Shin Araki, Masuhiro Ikeda, Kiyomi Yamatsu, and Shinro Tachibana pp 206 - 212; DOI: 10.1021/jm00163a034 |
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Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins Joseph I. DeGraw, Pamela H. Christie, Roy L. Kisliuk, Yvette Gaumont, and Francis M. Sirotnak pp 212 - 215; DOI: 10.1021/jm00163a035 |
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Synthesis and .beta.-adrenergic antagonist activity of stereoisomeric practolol and propranolol derivatives Katerina Leftheris and Murray Goodman pp 216 - 223; DOI: 10.1021/jm00163a036 |
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Antihypertensive dihydropyridines with 1,4,4-trisubstitution Michael J. Kukla, Henry J. Breslin, and Alan Gill pp 223 - 228; DOI: 10.1021/jm00163a037 |
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Synthesis of thromboxane receptor antagonists with bicyclo[3.1.0]hexane ring systems Susumu Kamata, Nobuhiro Haga, Tatsuo Tsuri, Kiyohisa Uchida, Hisato Kakushi, Hitoshi Arita, and Kohji Hanasaki pp 229 - 239; DOI: 10.1021/jm00163a038 |
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N-[(Arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure John H. Musser, Anthony F. Kreft, Reinhold H. W. Bender, Dennis M. Kubrak, David Grimes, Richard P. Carlson, James M. Hand, and Joseph Chang pp 240 - 245; DOI: 10.1021/jm00163a039 |
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Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules Victoria F. Roche, Edward B. Roche, Paul K. Lemcke, William S. Wire, and Thomas F. Burks pp 245 - 248; DOI: 10.1021/jm00163a040 |
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[Cyclic] [D-Pen2,D-Pen5]enkephalin analogs with increased affinity and selectivity for .delta.-opioid receptors Geza Toth, Thomas H. Kramer, Richard Knapp, George Lui, Peg Davis, Thomas F. Burks, Henry I. Yamamura, and Victor J. Hruby pp 249 - 253; DOI: 10.1021/jm00163a041 |
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Alkylation of DNA by C-10 of 2,7-diaminomitosene Bhashyam S. Iyengar, Robert T. Dorr, Nancy G. Shipp, and William A. Remers pp 253 - 257; DOI: 10.1021/jm00163a042 |
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Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS - associated neurological disorders Eduardo Palomino, Bernard R. Meltsner, David Kessel, and Jerome P. Horwitz pp 258 - 263; DOI: 10.1021/jm00163a043 |
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Phosphoramidate peptide inhibitors of human skin fibroblast collagenase Zbigniew P. Kortylewicz and Richard E. Galardy pp 263 - 273; DOI: 10.1021/jm00163a044 |
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1-(Substituted-benzyl)imidazole-2(3H)thione inhibitors of dopamine .beta.-hydroxylase Benjamin J. Burke and A. J. Hopfinger pp 274 - 281; DOI: 10.1021/jm00163a045 |
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Tertiary (2-haloethyl)amine derivatives of the muscarinic agent McN-A-343, [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride Bjoern Ringdahl, Charlotta Mellin, Frederick J. Ehlert, Margareth Roch, Kathleen M. Rice, and Donald J. Jenden pp 281 - 286; DOI: 10.1021/jm00163a046 |
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Highly selective .kappa.-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted cyclohexyl]arylacetamide derivatives Paul R. Halfpenny, David C. Horwell, John Hughes, John C. Hunter, and David C. Rees pp 286 - 291; DOI: 10.1021/jm00163a047 |
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Cephalosporins to carbapenems: 1-oxygenated carbapenems and carbapenams Robert L. Rosati, Leilani V. Kapili, Peter Morrissey, and James A. Retsema pp 291 - 297; DOI: 10.1021/jm00163a048 |
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Cationic antiprotozoal drugs. Trypanocidal activity of 2-(4'-formylphenyl)imidazo[1,2-a]pyridinium guanylhydrazones and related derivatives of quaternary heteroaromatic compounds Richard J. Sundberg, Daniel J. Dahlhausen, G. Manikumar, B. Mavunkel, A. Biswas, V. Srinivasan, H. A. Musallam, Willis A. Reid, and Arba L. Ager pp 298 - 307; DOI: 10.1021/jm00163a049 |
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Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: profile of antimuscarinic efficacy and selectivity Vicki H. Audia, Daniel W. McPherson, Moshe Weitzberg, W. Janusz Rzeszotarski, Bonnie Sturm, James F. Kachur, Mary Abreu, and Carl Kaiser pp 307 - 310; DOI: 10.1021/jm00163a050 |
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4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties Juan C. Jaen, Lawrence D. Wise, Bradley W. Caprathe, Haile Tecle, Stephen Bergmeier, Christine C. Humblet, Thomas G. Heffner, Leonard T. Meltzer, and Thomas A. Pugsley pp 311 - 317; DOI: 10.1021/jm00163a051 |
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Synthesis and cardiotonic activity of novel biimidazoles Donald P. Matthews, James R. McCarthy, Jeffrey P. Whitten, Philip R. Kastner, Charlotte L. Barney, Franklin N. Marshall, Marcia A. Ertel, Therese Burkhard, Philip J. Shea, and Takashi Kariya pp 317 - 327; DOI: 10.1021/jm00163a052 |
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N-Phenyl-2-pyridinecarbothioamides as gastric mucosal protectants William A. Kinney, Nancy E. Lee, Robert M. Blank, Christopher A. Demerson, Carol S. Sarnella, Noreen T. Scherer, G. Nabi Mir, Luis E. Borella, John F. DiJoseph, and Cheryl Wells pp 327 - 336; DOI: 10.1021/jm00163a053 |
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Growth inhibition and induction of cellular differentiation of human myeloid leukemia cells in culture by carbamoyl congeners of ribavirin Yogesh S. Sanghvi, Birendra K. Bhattacharya, Ganesh D. Kini, Steven S. Matsumoto, Steven B. Larson, Weldon B. Jolley, Roland K. Robins, and Ganapathi R. Revankar pp 336 - 344; DOI: 10.1021/jm00163a054 |
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Orally effective acid prodrugs of the .beta.-lactamase inhibitor sulbactam Arthur R. English, Dennis Girard, V. John Jasys, Robert J. Martingano, and Michael S. Kellogg pp 344 - 347; DOI: 10.1021/jm00163a055 |
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Atrial natriuretic peptide receptor modulators: effects of disubstituted quinazolines on receptor binding and in vitro biological activity Melvin J. Yu, Jefferson R. McCowan, Mitchell I. Steinberg, Sally A. Wiest, Virginia L. Wyss, and Jong Sin Horng pp 348 - 353; DOI: 10.1021/jm00163a056 |
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Thymosin-like peptides as potential immunostimulants. Synthesis via the polymeric-reagent method Michael Mokotoff, Ming Zhao, Steven M. Roth, Jean A. Shelley, Joseph N. Slavoski, and Nicola M. Kouttab pp 354 - 360; DOI: 10.1021/jm00163a057 |
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2-Substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity Douglas G. Batt, George D. Maynard, Joseph J. Petraitis, Joan E. Shaw, William Galbraith, and Richard R. Harris pp 360 - 370; DOI: 10.1021/jm00163a058 |
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Renin inhibitors based on dipeptide analogs. Incorporation of the hydroxyethylene isostere at the P2/P3 sites Dale Kempf, Ed De Lara, Herman H. Stein, Jerome Cohen, David A. Egan, and Jacob J. Plattner pp 371 - 374; DOI: 10.1021/jm00163a059 |
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Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors Ulf Madsen, Lotte Brehm, Kjeld Schaumburg, Flemming S. Joergensen, and Povl Krogsgaard-Larsen pp 374 - 380; DOI: 10.1021/jm00163a060 |
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6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents Donald W. Combs, Marianne S. Rampulla, Stanley C. Bell, Dieter H. Klaubert, Alfonso J. Tobia, Robert Falotico, Barbara Haertlein, Constance Lakas-Weiss, and John B. Moore pp 380 - 386; DOI: 10.1021/jm00163a061 |
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Synthesis and serotonin binding site studies of some conformationally restricted indolylethylamine analogs based on 2-amino-3-(3'-indolyl)bicyclo[2.2.2]octane M. F. Schlecht, D. Tsarouhtsis, M. N. Lipovac, and E. A. Debler pp 386 - 394; DOI: 10.1021/jm00163a062 |
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Synthesis of peptidyl fluoromethyl ketones and peptidyl .alpha.-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G Norton P. Peet, Joseph P. Burkhart, Michael R. Angelastro, Eugene L. Giroux, Shujaath Mehdi, Philippe Bey, Michael Kolb, Bernhard Neises, and Daniel Schirlin pp 394 - 407; DOI: 10.1021/jm00163a063 |
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Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-.beta.-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents Katsuhiko Nagahara, Jack D. Anderson, Ganesh D. Kini, N. Kent Dalley, Steven B. Larson, Donald F. Smee, Ai Jin, Brahma S. Sharma, Weldon B. Jolley, and et al. pp 407 - 415; DOI: 10.1021/jm00163a064 |
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Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups C. David Jones, Mark A. Winter, Kenneth S. Hirsch, Nancy Stamm, Harold M. Taylor, Howard E. Holden, James D. Davenport, Eriks V. Krumkalns, and Robert G. Suhr pp 416 - 429; DOI: 10.1021/jm00163a065 |
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Synthesis and structure-affinity of a series of 7.alpha.-undecylestradiol derivatives: a potential vector for therapy and imaging of estrogen-receptor-positive cancers Jean N. DaSilva and Johan E. Van Lier pp 430 - 434; DOI: 10.1021/jm00163a066 |
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Antifolate and antibacterial activities of 5-substituted 2,4-diaminoquinazolines Neil V. Harris, Christopher Smith, and Keith Bowden pp 434 - 444; DOI: 10.1021/jm00163a067 |
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Synthesis and dopamine agonist properties of (+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol and its enantiomers Horace A. DeWald, Thomas G. Heffner, Juan C. Jaen, David M. Lustgarten, Andrew T. McPhail, Leonard T. Meltzer, Thomas A. Pugsley, and Lawrence D. Wise pp 445 - 450; DOI: 10.1021/jm00163a068 |
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Cholecystokinin-A receptor ligands based on the .kappa.-opioid agonist tifluadom Mark G. Bock, Robert M. DiPardo, Ben E. Evans, Kenneth E. Rittle, Willie L. Whitter, Daniel F. Veber, Roger M. Freidinger, Raymond S. L. Chang, T. B. Chen, and Victor J. Lotti pp 450 - 455; DOI: 10.1021/jm00163a069 |
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Editorial - Ethical Guidelines to Publication of Chemical Research Philip S. Portoghese pp 1 - 3; DOI: 10.1021/jm00163a600 |
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Book Reviews pp 456 - 460; DOI: 10.1021/jm00163a601 |
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N5-Acetyl-N5-hydroxy-L-ornithine-derived siderophore-carbacephalosporin .beta.-lactam conjugates: iron transport mediated drug delivery E. Kurt Dolence, Albert A. Minnick, and Marvin J. Miller pp 461 - 464; DOI: 10.1021/jm00164a001 |
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Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase Allen Krantz, Robin W. Spencer, Tim F. Tam, Teng Jiam Liak, Leslie J. Copp, Everton M. Thomas, and Steven P. Rafferty pp 464 - 479; DOI: 10.1021/jm00164a002 |
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Synthesis and biological activity of novel vitamin D analogs: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-difluoro-1.alpha.,25-dihydroxy-26,27-dimethylvitamin D3 Harpal S. Gill, James M. Londowski, Robert A. Corradino, Alan R. Zinsmeister, and Rajiv Kumar pp 480 - 490; DOI: 10.1021/jm00164a003 |
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Antitumor properties of tetrahydrobenz(a)anthraquinone derivatives Charles E. Morreal, Ralph J. Bernacki, Marilyn Hillman, Alice Atwood, and Donna Cartonia pp 490 - 492; DOI: 10.1021/jm00164a004 |
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Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzopyrans and related compounds, new potassium channel activators Rolf Bergmann and Rolf Gericke pp 492 - 504; DOI: 10.1021/jm00164a005 |
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Synthesis and antiinflammatory activity of cis- and trans-6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepinacetic and -oxepinacetic acids Mikio Kurokawa, Hitoshi Uno, Hideo Nakamura, Fuminori Sato, and Shunsuke Naruto pp 504 - 509; DOI: 10.1021/jm00164a006 |
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Aldosterone antagonists. 3. Synthesis and activities of steroidal 7.alpha.-(alkoxycarbonyl)-15,16-methylene spirolactones Klaus Nickisch, Dieter Bittler, Henry Laurent, Wolfgang Losert, Yukishige Nishino, Ekkehard Schillinger, and Rudolf Wiechert pp 509 - 513; DOI: 10.1021/jm00164a007 |
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Conformation-activity relationship of sweet molecules. Comparison of aspartame and naphthimidazolesulfonic acids M. A. Castiglione-Morelli, F. Lelj, F. Naider, M. Tallon, T. Tancredi, and P. A. Temussi pp 514 - 520; DOI: 10.1021/jm00164a008 |
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Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine John L. Neumeyer, Nandkishore Baindur, Jun Yuan, Gillian Booth, Phillip Seeman, and Hyman B. Niznik pp 521 - 526; DOI: 10.1021/jm00164a009 |
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogs of 4-(arylamino)quinolines Thomas H. Brown, Robert J. Ife, David J. Keeling, Shiona M. Laing, Colin A. Leach, Michael E. Parsons, Carolyn A. Price, David R. Reavill, and Kenneth J. Wiggall pp 527 - 533; DOI: 10.1021/jm00164a010 |
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New inhibitors of renin that contain novel phosphostatine Leu-Val replacements Joseph F. Dellaria, Robert G. Maki, Herman H. Stein, Jerome Cohen, David Whittern, Kennan Marsh, Daniel J. Hoffman, Jacob J. Plattner, and Thomas J. Perun pp 534 - 542; DOI: 10.1021/jm00164a011 |
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Antiulcer agents. 4-Substituted 2-guanidinothiazoles: reversible, competitive, and selective inhibitors of gastric H+,K+-ATPase John L. LaMattina, Peter A. McCarthy, Lawrence A. Reiter, William F. Holt, and Li An Yeh pp 543 - 552; DOI: 10.1021/jm00164a012 |
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Hypolipidemic activity of rifamycin derivatives Peter Traxler, Wilhelm Kump, Klaus Mueller, and Werner Tosch pp 552 - 560; DOI: 10.1021/jm00164a013 |
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Synthesis and biological activity of an acyclic analog of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid James L. Kelley, Ed W. McLean, Naomi K. Cohn, Mark P. Edelstein, David S. Duch, Gary K. Smith, Mary H. Hanlon, and Robert Ferone pp 561 - 567; DOI: 10.1021/jm00164a014 |
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Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids Anjum Muzaffar, Arnold Brossi, Chii M. Lin, and Ernest Hamel pp 567 - 571; DOI: 10.1021/jm00164a015 |
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1,2,4-Diazaphosphole nucleosides. Synthesis, structure, and antitumor activity of nucleosides with a .lambda.3 phosphorus atom Timothy A. Riley, Steven B. Larson, Thomas L. Avery, Rick A. Finch, and Roland K. Robins pp 572 - 576; DOI: 10.1021/jm00164a016 |
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Hemicholinium-3 congeners as potential antagonists to organophosphate-induced toxicity Joseph G. Cannon, M. Fethi Sahin, John Paul Long, Jan R. Flynn, and Ranbir K. Bhatnagar pp 577 - 579; DOI: 10.1021/jm00164a017 |
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.beta.-Lactam analogs of oxotremorine. 3- and 4-Methyl-substituted 2-azetidinones Bjoern M. Nilsson, Bjorn Ringdahl, and Uli Hacksell pp 580 - 584; DOI: 10.1021/jm00164a018 |
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Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists David Alker, Simon F. Campbell, Peter E. Cross, Roger A. Burges, Anthony J. Carter, and Donald G. Gardiner pp 585 - 591; DOI: 10.1021/jm00164a019 |
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Novel glutamic acid-derived cholecystokinin receptor ligands R. M. Freidinger, W. L. Whitter, N. P. Gould, M. K. Holloway, R. S. L. Chang, and V. J. Lotti pp 591 - 595; DOI: 10.1021/jm00164a020 |
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Affinity of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for .alpha.-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled .alpha.2-adrenoceptor vs the [3H]yohimbine-labeled site Robin D. Clark, Jacob Berger, Pushkal Garg, Klaus K. Weinhardt, Michael Spedding, Andrew T. Kilpatrick, Christine M. Brown, and Alison C. MacKinnon pp 596 - 600; DOI: 10.1021/jm00164a021 |
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Aporphines as antagonists of dopamine D-1 receptors John M. Schaus, Robert D. Titus, Mark M. Foreman, Norman R. Mason, and Lewis L. Truex pp 600 - 607; DOI: 10.1021/jm00164a022 |
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Design, synthesis, testing, and quantitative structure-activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate as new antiviral agents against coronavirus Pou Hsiung Wang, James G. Keck, Eric J. Lien, and Michael M. C. Lai pp 608 - 614; DOI: 10.1021/jm00164a023 |
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Potential antisecretory antidiarrheals. 2. .alpha.2-Adrenergic 2-[(aryloxy)alkyl]imidazolines Alan E. Moormann, Barnett S. Pitzele, P. H. Jones, Gary W. Gullikson, David Albin, Stella S. Yu, Robert G. Bianchi, Elizabeth L. Sanguinetti, Barbara Rubin, and et al. pp 614 - 626; DOI: 10.1021/jm00164a024 |
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Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents Gary B. Phillips, Thomas K. Morgan, Klaus Nickisch, Joan M. Lind, Robert P. Gomez, Ronald A. Wohl, Thomas M. Argentieri, and Mark E. Sullivan pp 627 - 633; DOI: 10.1021/jm00164a025 |
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1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the .alpha.2-adrenoceptor and the 5-HT1A receptor Robin D. Clark, Klaus K. Weinhardt, Jacob Berger, Lawrence E. Fisher, Christine M. Brown, Alison C. MacKinnon, Andrew T. Kilpatrick, and Michael Spedding pp 633 - 641; DOI: 10.1021/jm00164a026 |
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Total synthesis of the four stereoisomers of dihexadecanoyl phosphatidylinositol and the substrate stereospecificity of human erythrocyte membrane phosphatidylinositol 4-kinase Rodney C. Young, C. Peter Downes, Drake S. Eggleston, Martin Jones, Colin H. Macphee, Kishore K. Rana, and John G. Ward pp 641 - 646; DOI: 10.1021/jm00164a027 |
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Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl substituted dihydropyridines John L. Archibald, Gerald Bradley, Albert Opalko, Terence J. Ward, Janet C. White, Christine Ennis, and Nicholas B. Shepperson pp 646 - 652; DOI: 10.1021/jm00164a028 |
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(8.beta.)-6-Methylergoline amide derivatives as serotonin antagonists: N1-substituent effects on vascular 5HT2 receptor activity Jerry W. Misner, William L. Garbrecht, Gifford Marzoni, Kathleen R. Whitten, and Marlene L. Cohen pp 652 - 656; DOI: 10.1021/jm00164a029 |
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Antimitotic agents. Synthesis of imidazo[4,5-c]pyridin-6-ylcarbamates and imidazo[4,5-b]pyridin-5-ylcarbamates Carroll Temple pp 656 - 661; DOI: 10.1021/jm00164a030 |
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Synthesis and biological activity of atrial natriuretic factor analogs: effect of modifications to the disulfide bridge John DiMaio, Jorge Jaramillo, Dominik Wernic, Louis Grenier, Ewald Welchner, and Julian Adams pp 661 - 667; DOI: 10.1021/jm00164a031 |
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Autoxidation of the serotonergic neurotoxin 5,7-dihydroxytryptamine Tahereh Tabatabaie, Monika Z. Wrona, and Glenn Dryhurst pp 667 - 672; DOI: 10.1021/jm00164a032 |
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Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogs of methotrexate and tetrahydrofolic acid Joseph I. DeGraw, Pamela H. Christie, Roy L. Kisliuk, Yvette Gaumont, and Francis M. Sirotnak pp 673 - 677; DOI: 10.1021/jm00164a033 |
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Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2 Caroline J. Springer, Pari Antoniw, Bagshawe, Frances Searle, Graham M. F. Bisset, and Michael Jarman pp 677 - 681; DOI: 10.1021/jm00164a034 |
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The preparation of 2'-deoxy-2'-fluoro-1',2'-seconucleosides as potential antiviral agents Purushotham Vemishetti, Racha Saibaba, Raymond P. Panzica, and Elie Abushanab pp 681 - 686; DOI: 10.1021/jm00164a035 |
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Structure-activity correlations for psychotomimetics. 1. Phenylalkylamines: electronic, volume, and hydrophobicity parameters Brian W. Clare pp 687 - 702; DOI: 10.1021/jm00164a036 |
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Nonneurotoxic tetralin and indan analogs of 3,4-(methylenedioxy)amphetamine (MDA) David E. Nichols, William K. Brewster, Michael P. Johnson, Robert Oberlender, and Robert M. Riggs pp 703 - 710; DOI: 10.1021/jm00164a037 |
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Folate analogs. 33. Synthesis of folate and antifolate poly-.gamma.-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells Ann Abraham, M. G. Nair, R. L. Kisliuk, J. Galivan, and Y. Gaumont pp 711 - 717; DOI: 10.1021/jm00164a038 |
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Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine Rakesh Kumar, Lihua Xu, Edward E. Knaus, Leonard I. Wiebe, Dorothy R. Tovell, D. Lorne Tyrrell, and Theresa M. Allen pp 717 - 723; DOI: 10.1021/jm00164a039 |
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Synthesis and inhibitory potency of peptides corresponding to the subunit 2 C-terminal region of herpes virus ribonucleotide reductases Pierrette Gaudreau, Helene Paradis, Yves Langelier, and Paul Brazeau pp 723 - 730; DOI: 10.1021/jm00164a040 |
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Methylating agents as trypanocides Philip G. Penketh, Krishnamurthy Shyam, Alan A. Divo, Curtis L. Patton, and Alan C. Sartorelli pp 730 - 732; DOI: 10.1021/jm00164a041 |
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Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor .gamma.-vinyl-GABA James N. Jacob, Gary W. Hesse, and Victor E. Shashoua pp 733 - 736; DOI: 10.1021/jm00164a042 |
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Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6.alpha.- and 6.beta.-naltrexol Leslie D. Olsen, Peter Klein, Wendel L. Nelson, Yi He Yao, and Eric J. Simon pp 737 - 741; DOI: 10.1021/jm00164a043 |
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Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides Barton J. Bradbury, Jesse Baumgold, and Kenneth A. Jacobson pp 741 - 748; DOI: 10.1021/jm00164a044 |
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Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides Samuel L. Graham, Jacob M. Hoffman, Pierre Gautheron, Stuart R. Michelson, Thomas H. Scholz, Harvey Schwam, Kenneth L. Shepard, Anthony M. Smith, Robert L. Smith, and et al. pp 749 - 754; DOI: 10.1021/jm00164a045 |
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5-HT1 and 5-HT2 binding profiles of the serotonergic agents .alpha.-methylserotonin and 2-methylserotonin Abd M. Ismaiel, Milt Titeler, Keith J. Miller, Thomas S. Smith, and Richard A. Glennon pp 755 - 758; DOI: 10.1021/jm00164a046 |
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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 6. trans-6-[2-(Substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones John D. Prugh, Alfred W. Alberts, Albert A. Deana, James L. Gilfillian, Jesse W. Huff, Robert L. Smith, and J. Mark Wiggins pp 758 - 765; DOI: 10.1021/jm00164a047 |
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Lipophilic 1,3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids as biological mimics of the ionophore antibiotics Frank J. Urban, Larry R. Chappel, Arthur E. Girard, Banavara L. Mylari, and Ian J. Pimblett pp 765 - 771; DOI: 10.1021/jm00164a048 |
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Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein Laurent G. Boulu, Gordon M. Crippen, Hugh A. Barton, Hoonjeong Kwon, and Michael A. Marletta pp 771 - 775; DOI: 10.1021/jm00164a049 |
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1,4-Dihydronaphthoquinones, hydroindoloquinones, benzofurans, and benzothiophenes as inhibitors of 5-lipoxygenase. Synthesis and structure-activity studies Ayako Yamashita, Robert G. Schaub, Michael K. Bach, Gordon J. White, Arthur Toy, Nabil B. Ghazal, Michael D. Burdick, John R. Brashler, and Marilyn S. Holm pp 775 - 781; DOI: 10.1021/jm00164a050 |
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Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine .beta.-hydroxylase. 4. Structure-activity relationships at the copper binding site Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf, Joseph A. Finkelstein, James S. Frazee, Eileen L. Hilbert, Stephen T. Ross, Kathryn E. Flaim, and John L. Sawyer pp 781 - 789; DOI: 10.1021/jm00164a051 |
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Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists Wayne J. Thompson, Paul S. Anderson, Susan F. Britcher, Terry A. Lyle, J. Eric Thies, Catherine A. Magill, Sandor L. Varga, John E. Schwering, Paulette A. Lyle, and et al. pp 789 - 808; DOI: 10.1021/jm00164a052 |
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Chloro-substituted, sterically hindered 5,11-dicarbo analogs of clozapine as potential chiral antipsychotic agents Daniel A. Davis, Tomas De Paulis, Aaron Janowsky, and Howard E. Smith pp 809 - 814; DOI: 10.1021/jm00164a053 |
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Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of minimal DNA-intercalating agents which may not act via topoisomerase II William A. Denny, Gordon W. Rewcastle, and Bruce C. Baguley pp 814 - 819; DOI: 10.1021/jm00164a054 |
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Analogs of carbamyl aspartate as inhibitors of dihydroorotase: preparation of boronic acid transition-state analogs and a zinc chelator carbamylhomocysteine David H. Kinder, Sandra K. Frank, and Matthew M. Ames pp 819 - 823; DOI: 10.1021/jm00164a055 |
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An approach to trapping .gamma.-glutamyl radical intermediates proposed for vitamin K dependent carboxylase: .alpha.,.beta.-methyleneglutamic acid James T. Slama, Rajiv K. Satsangi, Anne Simmons, Vincent Lynch, Randall E. Bolger, and John Suttie pp 824 - 832; DOI: 10.1021/jm00164a056 |
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Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid Peter H. Nelson, Elsie Eugui, Ching C. Wang, and Anthony C. Allison pp 833 - 838; DOI: 10.1021/jm00164a057 |
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Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites James S. Kaltenbronn, J. P. Hudspeth, E. A. Lunney, B. M. Michniewicz, E. D. Nicolaides, J. T. Repine, W. H. Roark, M. A. Stier, F. J. Tinney, and et al. pp 838 - 845; DOI: 10.1021/jm00164a058 |
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Synthesis, antiretrovirus effects and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine Johann Hiebl, Erich Zbiral, Jan Balzarini, and Erik De Clercq pp 845 - 848; DOI: 10.1021/jm00164a059 |
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New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids Susan E. Hagen, John M. Domagala, Carl L. Heifetz, Joseph P. Sanchez, and Marjorie Solomon pp 849 - 854; DOI: 10.1021/jm00164a060 |
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N-Phenyl-N'-pyridinylureas as anticonvulsant agents Michael R. Pavia, Sandra J. Lobbestael, Charles P. Taylor, Fred M. Hershenson, and David L. Miskell pp 854 - 861; DOI: 10.1021/jm00164a061 |
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Glycolipids as host resistance stimulators Mitree M. Ponpipom, William K. Hagmann, Laura A. O'Grady, Jesse J. Jackson, David D. Wood, and Hans J. Zweerink pp 861 - 867; DOI: 10.1021/jm00164a062 |
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Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines Piet Wigerinck, Arthur Van Aerschot, Gerard Janssen, Paul Claes, Jan Balzarini, Erik De Clercq, and Piet Herdewijn pp 868 - 873; DOI: 10.1021/jm00164a063 |
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Studies on Ca2+ channel antagonists. A 2-diazo-3,3,3-trifluoropropionamide derivative related to verapamil as a potential photoaffinity probe Louis J. Theodore, Wendel L. Nelson, Bharti Dave, and John C. Giacomini pp 873 - 877; DOI: 10.1021/jm00164a064 |
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Design and synthesis of 14.alpha.-methyl-15-aza-D-homosterols as novel antimycotics Roland E. Dolle, H. S. Allaudeen, and Lawrence I. Kruse pp 877 - 880; DOI: 10.1021/jm00164a065 |
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Improved delivery through biological membranes. 39. Brain-specific chemical delivery systems for 26-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats [Erratum to document cited in CA111(8):63813y] Whei Mei Wu, Emil Pop, Efraim Shek, and Nicholas Bodor pp 880 - 880; DOI: 10.1021/jm00164a066 |
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Book Reviews pp 880 - 882; DOI: 10.1021/jm00164a600 |
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Molecular modeling software and methods for medicinal chemistry N. Claude Cohen, Jeffrey M. Blaney, Christine Humblet, Peter Gund, and David C. Barry pp 883 - 894; DOI: 10.1021/jm00165a001 |
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Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents Dennis M. Zimmerman and J. David Leander pp 895 - 902; DOI: 10.1021/jm00165a002 |
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4'-[(4-Piperidyl)carbonyl]methanesulfonanilides as potent, selective, bioavailable class III antiarrhythmic agents Hitoshi Oinuma, Kazutoshi Miyake, Motosuke Yamanaka, Kenichi Nomoto, Hiroshi Katoh, Kohei Sawada, Mitsumasa Shino, and Sachiyuki Hamano pp 903 - 905; DOI: 10.1021/jm00165a003 |
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Neural networks applied to structure-activity relationships Tomoo Aoyama, Yuji Suzuki, and Hiroshi Ichikawa pp 905 - 908; DOI: 10.1021/jm00165a004 |
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Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent Milton L. Hammond, Robert A. Zambias, Michael N. Chang, Norman P. Jensen, John McDonald, Kathryn Thompson, David A. Boulton, Ihor E. Kopka, Karen M. Hand, and et al. pp 908 - 918; DOI: 10.1021/jm00165a005 |
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Preparation and anticonvulsant activity of a series of functionalized .alpha.-aromatic and .alpha.-heteroaromatic amino acids Harold Kohn, Kailash N. Sawhney, Philippe LeGall, Judith D. Conley, David W. Robertson, and J. David Leander pp 919 - 926; DOI: 10.1021/jm00165a006 |
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Synthesis and anticonvulsant activity of 2-benzylglutarimides R. Richard Goehring, Thomas D. Greenwood, Godson C. Nwokogu, Jyothi S. Pisipati, Tommie G. Rogers, and James F. Wolfe pp 926 - 931; DOI: 10.1021/jm00165a007 |
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Selective inhibition of .gamma.-aminobutyric acid aminotransferase by (3R,4R), (3S,4S)- and (3R,4S), (3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids Richard B. Silverman and Shrenik M. Nanavati pp 931 - 936; DOI: 10.1021/jm00165a008 |
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Steroidal A ring aryl carboxylic acids: a new class of steroid 5.alpha.-reductase inhibitors Dennis A. Holt, Mark A. Levy, David L. Ladd, Hye Ja Oh, Jill M. Erb, Julie I. Heaslip, Martin Brandt, and Brian W. Metcalf pp 937 - 942; DOI: 10.1021/jm00165a009 |
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Inhibition of steroid 5.alpha.-reductase by unsaturated 3-carboxy steroids Dennis A. Holt, Mark A. Levy, Hye Ja Oh, Jill M. Erb, Julie I. Heaslip, Martin Brandt, Hsuan Yin Lan-Hargest, and Brian W. Metcalf pp 943 - 950; DOI: 10.1021/jm00165a010 |
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Novel [(diazomethyl)carbonyl]-1,2,3,4-tetrahydronaphthalene derivatives as potential photoaffinity ligands for the 5-HT1A receptor Toni B. Kline, David L. Nelson, and Krishnan Namboodiri pp 950 - 955; DOI: 10.1021/jm00165a011 |
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Neuronal mapping of the heart with 6-[18F]fluorometaraminol Donald M. Wieland, Karen C. Rosenspire, Gary D. Hutchins, Marcian Van Dort, Jill M. Rothley, Suresh G. Mislankar, Helen T. Lee, Christopher C. Massin, David L. Gildersleeve, and et al. pp 956 - 964; DOI: 10.1021/jm00165a012 |
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Small peptide inhibitors of smooth muscle myosin light chain kinase Federico C. A. Gaeta, Laura S. Lehman de Gaeta, Timothy P. Kogan, Yat Sun Or, Carolyn Foster, and Michael Czarniecki pp 964 - 972; DOI: 10.1021/jm00165a013 |
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Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogs of camptothecin Allan W. Nicholas, Mansukh C. Wani, Govindarajan Manikumar, Monroe E. Wall, Kurt W. Kohn, and Yves Pommier pp 972 - 978; DOI: 10.1021/jm00165a014 |
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Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV Victor E. Marquez, Christopher K. H. Tseng, Hiroaki Mitsuya, Shizuko Aoki, James A. Kelley, Harry Ford, Jeri S. Roth, Samuel Broder, David G. Johns, and John S. Driscoll pp 978 - 985; DOI: 10.1021/jm00165a015 |
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Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C Canio J. Marasco, Claude Piantadosi, Karen L. Meyer, Susan Morris-Natschke, Khalid S. Ishaq, George W. Small, and Larry W. Daniel pp 985 - 992; DOI: 10.1021/jm00165a016 |
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Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships James B. Summers, Ki H. Kim, Hormoz Mazdiyasni, James H. Holms, James D. Ratajczyk, Andrew O. Stewart, Richard D. Dyer, and George W. Carter pp 992 - 998; DOI: 10.1021/jm00165a017 |
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Synthesis, conformation, and immunosuppressive activities of three analogs of cyclosporin A modified in the 1-position Johannes D. Aebi, Donald T. Deyo, Chong Qing Sun, Dominique Guillaume, Brian Dunlap, and Daniel H. Rich pp 999 - 1009; DOI: 10.1021/jm00165a018 |
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NMR studies of the conjugation of mechlorethamine with glutathione Michael P. Gamcsik, Terence G. Hamill, and Michael Colvin pp 1009 - 1014; DOI: 10.1021/jm00165a019 |
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Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model Tommy Liljefors, Klaus P. Boegesoe, John Hyttel, Haakan Wikstroem, Kjell Svensson, and Arvid Carlsson pp 1015 - 1022; DOI: 10.1021/jm00165a020 |
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Synthesis of N-[N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]-.gamma.-glutamate, an unusual substrate for folylpoly-.gamma.-glutamate synthetase and .gamma.-glutamyl hydrolase Nicholas J. Licato, James K. Coward, Zenia Nimec, John Galivan, Wanda E. Bolanowska, and John J. McGuire pp 1022 - 1027; DOI: 10.1021/jm00165a021 |
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Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (.+-.)-(5Z)-7-[(3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-exo-yl]heptenoic acid Mitsuaki Ohtani and Masayuki Narisada pp 1027 - 1031; DOI: 10.1021/jm00165a022 |
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A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors Mark R. Seggel, M. Y. Yousif, Robert A. Lyon, Milt Titeler, Bryan L. Roth, Eva A. Suba, and Richard A. Glennon pp 1032 - 1036; DOI: 10.1021/jm00165a023 |
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Cannabimimetic activity of novel enantiomeric, benzofuran cannabinoids Raphael Mechoulam, Aviva Breuer, Tobjorn U. C. Jaerbe, Arto J. Hiltunen, and Robert Glaser pp 1037 - 1043; DOI: 10.1021/jm00165a024 |
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Binding of cis-(1,2-diaminocyclohexane)platinum(II) and its derivatives to duplex DNA Kenneth J. Miller, Sharon L. McCarthy, and Morris Krauss pp 1043 - 1046; DOI: 10.1021/jm00165a025 |
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Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) Terry A. Lyle, Catherine A. Magill, Susan F. Britcher, George H. Denny, Wayne J. Thompson, Joan S. Murphy, Antony R. Knight, John A. Kemp, George R. Marshall, and et al. pp 1047 - 1052; DOI: 10.1021/jm00165a026 |
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High potency dipeptide sweeteners. 1. L-Aspartyl-D-phenylglycine esters J. M. Janusz, J. M. Gardlik, P. A. Young, R. V. Burkes, S. J. Stoll, A. F. Estelle, and C. M. Riley pp 1052 - 1061; DOI: 10.1021/jm00165a027 |
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Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogs of 6-(benzyloxy)-4-(methoxymethyl)-.beta.-carboline-3-carboxylic acid ethyl ester Sean P. Hollinshead, Mark L. Trudell, Phil Skolnick, and James M. Cook pp 1062 - 1069; DOI: 10.1021/jm00165a028 |
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Synthesis and structure-activity relationship of C5-substituted analogs of (.+-.)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine [(.+-.)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site James A. Monn, Andrew Thurkauf, Mariena V. Mattson, Arthur E. Jacobson, and Kenner C. Rice pp 1069 - 1076; DOI: 10.1021/jm00165a029 |
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A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate B. L. Chenard, C. A. Lipinski, B. W. Dominy, E. E. Mena, R. T. Ronau, G. C. Butterfield, L. C. Marinovic, M. Pagnozzi, T. W. Butler, and T. Tsang pp 1077 - 1083; DOI: 10.1021/jm00165a030 |
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Book Reviews pp 1083 - 1084; DOI: 10.1021/jm00165a600 |
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Inhibitors of human leukocyte proteinase-3 W. C. Groutas, J. R. Hoidal, M. J. Brubaker, M. A. Stanga, R. Venkataraman, B. H. Gray, and N. V. Rao pp 1085 - 1087; DOI: 10.1021/jm00166a001 |
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Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities Thomas K. Morgan Jr., Randall Lis, William C. Lumma Jr., Ronald A. Wohl, Klaus Nickisch, Gary B. Phillips, Joan M. Lind, John W. Lampe, Susan V. Di Meo, and et al. pp 1087 - 1090; DOI: 10.1021/jm00166a002 |
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Synthesis and cardiac electrophysiological activity of N-substituted-4-(1H-imidazol-1-yl)benzamides - new selective class III agents Thomas K. Morgan Jr., Randall Lis, William C. Lumma Jr., Klaus Nickisch, Ronald A. Wohl, Gary B. Phillips, Robert P. Gomez, John W. Lampe, Susan V. Di Meo, and et al. pp 1091 - 1097; DOI: 10.1021/jm00166a003 |
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Conformational analysis of cyproheptadine hydrochloride Maruse Sadek, David J. Craik, Jon G. Hall, and Peter R. Andrews pp 1098 - 1107; DOI: 10.1021/jm00166a004 |
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Chalcogenapyrylium dyes as photochemotherapeutic agents. 2. Tumor uptake, mitochondrial targeting, and singlet-oxygen-induced inhibition of cytochrome c oxidase Michael R. Detty, Paul B. Merkel, Russell Hilf, Scott L. Gibson, and Stephen K. Powers pp 1108 - 1116; DOI: 10.1021/jm00166a005 |
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Computer-aided molecular modeling of a thromboxane receptor antagonist S-145 and its related compounds Kiyoshi Ezumi, Masumi Yamakawa, and Masayuki Narisada pp 1117 - 1122; DOI: 10.1021/jm00166a006 |
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Dehydrogenase binding by tiazofurin anabolites Barry M. Goldstein, J. Ellis Bell, and Victor E. Marquez pp 1123 - 1127; DOI: 10.1021/jm00166a007 |
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Novel quinuclidine-based ligands for the muscarinic cholinergic receptor John Saunders, Mark Cassidy, Stephen B. Freedman, Elizabeth A. Harley, Leslie L. Iversen, Clare Kneen, Angus M. MacLeod, Kevin J. Merchant, Roger J. Snow, and Raymond Baker pp 1128 - 1138; DOI: 10.1021/jm00166a008 |
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Synthesis and .alpha.2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogs in human platelets Duane D. Miller, Akihiko Hamada, Michael T. Clark, Adeboye Adejare, Popat N. Patil, Gamal Shams, Karl J. Romstedt, Sung U. Kim, Urusa Intrasuksri, and et al. pp 1138 - 1144; DOI: 10.1021/jm00166a009 |
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Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma E. Jon Jacobsen, John M. McCall, Donald E. Ayer, Fred J. VanDoornik, John R. Palmer, Kenneth L. Belonga, J. Mark Braughler, Edward D. Hall, David J. Houser, and et al. pp 1145 - 1151; DOI: 10.1021/jm00166a010 |
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Selective class III antiarrhythmic agents. 1. Bis(arylalkyl)amines Peter E. Cross, John E. Arrowsmith, Geoffrey N. Thomas, Michael Gwilt, Roger A. Burges, and Alan J. Higgins pp 1151 - 1155; DOI: 10.1021/jm00166a011 |
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Potential antipsychotic agents. 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds Thomas Hoegberg, Stefan Bengtsson, Tomas De Paulis, Lars Johansson, Peter Stroem, Haakan Hall, and Sven Ove Oegren pp 1155 - 1163; DOI: 10.1021/jm00166a012 |
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Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes Rudolf Hanko, Michael D. Hammond, Romanis Fruchtmann, Joerg Pfitzner, and Graham A. Place pp 1163 - 1170; DOI: 10.1021/jm00166a013 |
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Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands Brian R. De Costa, Richard B. Rothman, Victor Bykov, Linda Band, Agu Pert, Arthur E. Jacobson, and Kenner C. Rice pp 1171 - 1176; DOI: 10.1021/jm00166a014 |
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DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard Trudi A. Gourdie, Kisione K. Valu, G. Lance Gravatt, Theodore J. Boritzki, Bruce C. Baguley, Laurence P. G. Wakelin, William R. Wilson, Paul D. Woodgate, and William A. Denny pp 1177 - 1186; DOI: 10.1021/jm00166a015 |
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Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships Raymond D. Youssefyeh, Ernest Magnien, Thomas D. Y. Lee, Wan Kit Chan, Clara J. Lin, Robert A. Galemmo Jr., William H. Johnson Jr., Jenny Tan, Henry F. Campbell, and et al. pp 1186 - 1194; DOI: 10.1021/jm00166a016 |
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Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity Fu Chih Huang, Robert A. Galemmo Jr., William H. Johnson Jr., Gregory B. Poli, Matthew M. Morrissette, James J. Mencel, James D. Warus, Henry F. Campbell, George W. Nuss, and et al. pp 1194 - 1200; DOI: 10.1021/jm00166a017 |
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Synthesis and biological evaluation of 14-alkoxymorphinans. 3. Extensive study on cyprodime-related compounds Helmut Schmidhammer, Colin F. C. Smith, Daniela Erlach, Martin Koch, Roland Krassnig, Wolfgang Schwetz, and Christine Wechner pp 1200 - 1206; DOI: 10.1021/jm00166a018 |
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Acyclic purine phosphonate analogs as antiviral agents. Synthesis and structure-activity relationships Choung Un Kim, Bing Yu Luh, Peter F. Misco, Joanne J. Bronson, Michael J. M. Hitchcock, Ismail Ghazzouli, and John C. Martin pp 1207 - 1213; DOI: 10.1021/jm00166a019 |
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Synthesis and biological evaluation of carbocyclic analogs of lyxofuranosides of 2-amino-6-substituted purines and 2-amino-6-substituted-8-azapurines Mark L. Peterson and Robert Vince pp 1214 - 1219; DOI: 10.1021/jm00166a020 |
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Synthesis and antitumor evaluation in mice of certain 7-deazapurine (pyrrolo[2,3-d]pyrimidine) and 3-deazapurine (imidazo[4,5-c]pyridine) nucleosides structurally related to sulfenosine, sulfinosine, and sulfonosine Kandasamy Ramasamy, Nobutaka Imamura, Naeem B. Hanna, Rick A. Finch, Thomas L. Avery, Roland K. Robins, and Ganapathi R. Revankar pp 1220 - 1225; DOI: 10.1021/jm00166a021 |
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Properties of the nucleic acid photoaffinity labeling agent 3-azidoamsacrine Tiee Leou Shieh, Patricia Hoyos, Eric Kolodziej, Joseph G. Stowell, William M. Baird, and Stephen R. Byrn pp 1225 - 1230; DOI: 10.1021/jm00166a022 |
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Preparation of triazolo[1,5-c]pyrimidines as potential antiasthma agents Jeffrey B. Medwid, Rolf Paul, Jannie S. Baker, John A. Brockman, Mila T. Du, William A. Hallett, J. William Hanifin, Robert A. Hardy Jr., M. Ernestine Tarrant, and et al. pp 1230 - 1241; DOI: 10.1021/jm00166a023 |
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Intrinsic isotope effects suggest that the reaction coordinate symmetry for the cytochrome P-450-catalyzed hydroxylation of octane is isozyme independent Jeffrey P. Jones, Allan E. Rettie, and William F. Trager pp 1242 - 1246; DOI: 10.1021/jm00166a024 |
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The synthesis and antibacterial activities of quinolones containing five- and six-membered heterocyclic substituents at the 7-position Curt S. Cooper, Pamela L. Klock, Daniel T. W. Chu, and Prabhavathi B. Fernandes pp 1246 - 1252; DOI: 10.1021/jm00166a025 |
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Analogs of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia Richard R. Tidwell, Susan Kilgore Jones, J. Dieter Geratz, Kwasi A. Ohemeng, Michael Cory, and James Edwin Hall pp 1252 - 1257; DOI: 10.1021/jm00166a026 |
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Diels-Alder adducts of vinyl porphyrins: synthesis and in vivo photodynamic effect against a rat bladder tumor Alan R. Morgan, Greta M. Garbo, Rick W. Keck, Robert A. Miller, Steven H. Selman, and Dimitris Skalkos pp 1258 - 1262; DOI: 10.1021/jm00166a027 |
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Synthesis of perfluoroalkylated xylitol ethers and esters: new surfactants for biomedical uses Leila Zarif, Jacques Greiner, Simonne Pace, and Jean G. Riess pp 1262 - 1269; DOI: 10.1021/jm00166a028 |
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Design and synthesis and propranolol analogs as serotonergic agents [Erratum to document cited in CA110(19):172847n] M. Edward Pierson, Robert A. Lyon, Milt Titeler, Steven B. Schulman, Paul Kowalski, and Richard A. Glennon pp 1270 - 1270; DOI: 10.1021/jm00166a029 |
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Synthesis and antiproliferative effects of novel 5'-fluorinated analogs of 5'-deoxy-5'-(methylthio)adenosine [Erratum to document cited in CA110(21):193314b] Janice R. Sufrin, Arthur J. Spiess, Debora L. Kramer, Paul R. Libby, and Carl W. Porter pp 1270 - 1270; DOI: 10.1021/jm00166a030 |
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Synthesis of the 2-chloro analogs of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents [Erratum to document cited in CA110(21):193310x] Andre Rosowsky, Vishnu C. Solan, Joseph G. Sodroski, and Ruth M. Ruprecht pp 1270 - 1270; DOI: 10.1021/jm00166a031 |
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Synthesis and biological properties of N63-carboxamides of teicoplanin antibiotics. Structure-activity relationships [Erratum to document cited in CA111(21):195401x] Adriano Malabarba, Aldo Trani, Paolo Strazzolini, Giuseppe Cietto, Pietro Ferrari, Giorgio Tarzia, Rosa Pallanza, and Marisa Berti pp 1270 - 1270; DOI: 10.1021/jm00166a032 |
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Book Reviews pp 1271 - 1274; DOI: 10.1021/jm00166a600 |
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Receptor triggering and receptor regulation: structure-activity relationships from the receptor's point of view Morley D. Hollenberg pp 1275 - 1281; DOI: 10.1021/jm00167a001 |
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Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS Daniel W. Norbeck, Earl Kern, Seiji Hayashi, William Rosenbrook, Hing Sham, Thomas Herrin, Jacob J. Plattner, John Erickson, Jacob Clement, and et al. pp 1281 - 1285; DOI: 10.1021/jm00167a002 |
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Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease Daniel H. Rich, Jeremy Green, Mihaly V. Toth, Garland R. Marshall, and Stephen B. H. Kent pp 1285 - 1288; DOI: 10.1021/jm00167a003 |
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Hypoxia-selective antitumor agents. 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogs with varying side chains: the "iminoacridan hypothesis" William A. Denny, Graham J. Atwell, Robert F. Anderson, and William R. Wilson pp 1288 - 1295; DOI: 10.1021/jm00167a004 |
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Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel Paul D. Leeson, Robert W. Carling, Kim James, Julian D. Smith, Kevin W. Moore, Erik H. F. Wong, and Raymond Baker pp 1296 - 1305; DOI: 10.1021/jm00167a005 |
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A model for compounds active against human rhinovirus-14 based on x-ray crystallography data Guy D. Diana, Adi M. Treasurywala, Thomas R. Bailey, Richard C. Oglesby, Daniel C. Pevear, and Frank J. Dutko pp 1306 - 1311; DOI: 10.1021/jm00167a006 |
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The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives John V. Duncia, Andrew T. Chiu, David J. Carini, George B. Gregory, Alexander L. Johnson, William A. Price, Gregory J. Wells, Pancras C. Wong, Joseph C. Calabrese, and Pieter B. M. W. M. Timmermans pp 1312 - 1329; DOI: 10.1021/jm00167a007 |
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Part VI. Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives David J. Carini, John V. Duncia, Alexander L. Johnson, Andrew T. Chiu, William A. Price, Pancras C. Wong, and Pieter B. M. W. Timmermans pp 1330 - 1336; DOI: 10.1021/jm00167a008 |
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Renin inhibitory peptides. A .beta.-aspartyl residue as a replacement for the histidyl residue at the P-2 site Suvit Thaisrivongs, Boryeu Mao, Donald T. Pals, Steve R. Turner, and Lisa T. Kroll pp 1337 - 1343; DOI: 10.1021/jm00167a009 |
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Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives D. Bouzard, P. Di Cesare, M. Essiz, J. P. Jacquet, J. R. Kiechel, P. Remuzon, A. Weber, T. Oki, M. Masuyoshi, and et al. pp 1344 - 1352; DOI: 10.1021/jm00167a010 |
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Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogs derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one J. Beres, G. Sagi, I. Tomoskozi, L. Gruber, E. Baitz-Gacs, L. Otvos, and E. De Clercq pp 1353 - 1360; DOI: 10.1021/jm00167a011 |
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Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines James L. Kelley, James A. Linn, and J. W. T. Selway pp 1360 - 1363; DOI: 10.1021/jm00167a012 |
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Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II Kuo Hsiung Lee, Scott A. Beers, Masami Mori, Zhe Qing Wang, Yao Haur Kuo, Li Li, Su Ying Liu, Jang Yang Chang, Fu Sheng Han, and Yung Chi Cheng pp 1364 - 1368; DOI: 10.1021/jm00167a013 |
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Polyamine analogs with antitumor activity Michael L. Edwards, N. J. Prakash, D. M. Stemerick, S. P. Sunkara, A. J. Bitonti, G. F. Davis, J. A. Dumont, and P. Bey pp 1369 - 1375; DOI: 10.1021/jm00167a014 |
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Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids Graham J. Atwell, Gordon W. Rewcastle, Bruce C. Baguley, and William A. Denny pp 1375 - 1379; DOI: 10.1021/jm00167a015 |
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Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-.beta.-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids Chung Il Hong, Alan J. Kirisits, Alexander Nechaev, David J. Buchheit, and Charles R. West pp 1380 - 1386; DOI: 10.1021/jm00167a016 |
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Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates Susan J. Berners-Price, Gerald R. Girard, David T. Hill, Blaine M. Sutton, Penelope S. Jarrett, Leo F. Faucette, Randall K. Johnson, Christopher K. Mirabelli, and Peter J. Sadler pp 1386 - 1392; DOI: 10.1021/jm00167a017 |
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Antitumor imidazotetrazines. 20. Preparation of the 8-acid derivative of mitozolomide and its utility in the preparation of active antitumor agents K. R. Horspool, M. F. G. Stevens, Christopher G. Newton, E. Lunt, R. J. A. Walsh, B. L. Pedgrift, G. U. Baig, F. Lavelle, and C. Fizames pp 1393 - 1399; DOI: 10.1021/jm00167a018 |
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Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells Stuart N. Farrow, A. Stanley Jones, Ajit Kumar, Richard T. Walker, Jan Balzarini, and Erik De Clercq pp 1400 - 1406; DOI: 10.1021/jm00167a019 |
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Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl)alkyl]benzamides Shiro Kato, Toshiya Morie, Katsuhiko Hino, Tatsuya Kon, Shunsuke Naruto, Naoyuki Yoshida, Tadahiko Karasawa, and Junichi Matsumoto pp 1406 - 1413; DOI: 10.1021/jm00167a020 |
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Synthesis, pharmacological effects, and conformation of 4,4-disubstituted 1,4-dihydropyridines Siegfried Goldmann, Liborius Born, Stanislav Kazda, Bernd Pittel, and Matthias Schramm pp 1413 - 1418; DOI: 10.1021/jm00167a021 |
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Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones Arie Zask, Ivo Jirkovsky, James W. Nowicki, and Michael L. McCaleb pp 1418 - 1423; DOI: 10.1021/jm00167a022 |
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Molecular design, synthesis, and antiinflammatory activity of a series of .beta.-aminoxypropionic acids Bruno Macchia, A. Balsamo, A. Lapucci, F. Macchia, A. Martinelli, S. Nencetti, E. Orlandini, M. Baldacci, G. Mengozzi, and et al. pp 1423 - 1430; DOI: 10.1021/jm00167a023 |
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Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60 Takeru Yamakawa, Hiroyuki Kagechika, Emiko Kawachi, Yuichi Hashimoto, and Koichi Shudo pp 1430 - 1437; DOI: 10.1021/jm00167a024 |
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Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogs of 10-substituted cannabidiol and 11- or 12-substituted .DELTA.8-tetrahydrocannabinol David R. Compton, Patrick J. Little, Billy R. Martin, Jeffery W. Gilman, Jayanta K. Saha, Vaman S. Jorapur, Howard P. Sard, and Raj K. Razdan pp 1437 - 1443; DOI: 10.1021/jm00167a025 |
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Synthesis, conformation, and immunosuppressive activity of cyclosporines that contain .epsilon.-oxygen (4R)-4-[(E)-butenyl]-4,N-dimethyl-L-threonine analogs in the 1-position Chong Qing Sun, Dominique Guillaume, Brian Dunlap, and Daniel H. Rich pp 1443 - 1452; DOI: 10.1021/jm00167a026 |
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Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogs Andrew Thurkauf, Brian De Costa, Shunichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner C. Rice, and Michael A. Rogawski pp 1452 - 1458; DOI: 10.1021/jm00167a027 |
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(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogs of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline Donald S. Karanewsky, Michael C. Badia, David W. Cushman, Jack M. DeForrest, Tamara Dejneka, Ving G. Lee, Melanie J. Loots, and Edward W. Petrillo pp 1459 - 1469; DOI: 10.1021/jm00167a028 |
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Synthesis and biological activity of some derivatives of rifamycin P B. Cavalleri, M. Turconi, G. Tamborini, E. Occelli, G. Cietto, R. Pallanza, R. Scotti, M. Berti, G. Romano, and F. Parenti pp 1470 - 1476; DOI: 10.1021/jm00167a029 |
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Structure-activity relationships for the carboxy-terminus-truncated analogs of angiotensin II, a new class of angiotensin II antagonists Philippe R. Bovy, Joan M. O'Neal, Gillian M. Olins, Dennis R. Patton, Ellen G. McMahon, Maria Palomo, John P. Koepke, Khadijeh S. Salles, Angelo J. Trapani, and et al. pp 1477 - 1482; DOI: 10.1021/jm00167a030 |
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N-(3-[18F]Fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography Paul L. Chesis, Dah Ren Hwang, and Michael J. Welch pp 1482 - 1490; DOI: 10.1021/jm00167a031 |
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Studies on hindered phenols and analogs. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity Yuichi Aizawa, Tsutomu Kanai, Kazuo Hasegawa, Takeshi Yamaguchi, Yoshio Iizuka, Teiki Iwaoka, and Takao Yoshioka pp 1491 - 1496; DOI: 10.1021/jm00167a032 |
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Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties Manfred Reiffen, Wolfgang Eberlein, Peter Mueller, Manfred Psiorz, Klaus Noll, Joachim Heider, Christian Lillie, Walter Kobinger, and Peter Luger pp 1496 - 1504; DOI: 10.1021/jm00167a033 |
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Synthesis and biological evaluation of prodrugs of zidovudine Sunil K. Aggarwal, Sudhir R. Gogu, S. R. S. Rangan, and Krishna C. Agrawal pp 1505 - 1510; DOI: 10.1021/jm00167a034 |
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Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines Karnail S. Atwal, George C. Rovnyak, Joseph Schwartz, Suzanne Moreland, Anders Hedberg, Jack Z. Gougoutas, Mary F. Malley, and David M. Floyd pp 1510 - 1515; DOI: 10.1021/jm00167a035 |
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Synthesis and antimalarial activity of (+)-deoxoartemisinin Mankil Jung, Xun Li, Daniel A. Bustos, Hala N. ElSohly, James D. McChesney, and Wilbur K. Milhous pp 1516 - 1518; DOI: 10.1021/jm00167a036 |
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Synthesis and antitumor activity of 1-[[(dialkylamino)alkyl]amino]-4-methyl-5H-pyrido[4,3-b]benzo[e]- and -benzo[g])indoles. A new class of antineoplastic agents Nguyen Chi Hung, Jean Marc Lhoste, Francois Lavelle, Marie Christine Bissery, and Emile Bisagni pp 1519 - 1528; DOI: 10.1021/jm00167a037 |
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Book Reviews pp 1528 - 1528; DOI: 10.1021/jm00167a600 |
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Potassium channel modulators: scientific applications and therapeutic promise David W. Robertson and Mitchell I. Steinberg pp 1529 - 1541; DOI: 10.1021/jm00168a001 |
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(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist Sven Erik Hillver, Lena Bjoerk, Yi Lin Li, Bjoern Svensson, Svante Ross, Nils Erik Anden, and Uli Hacksell pp 1541 - 1544; DOI: 10.1021/jm00168a002 |
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Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage Sang Ihn Kang and Colin Paul Spears pp 1544 - 1547; DOI: 10.1021/jm00168a003 |
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Naltrindole-5'-isothiocyanate: a nonequilibrium, highly selective .delta.-opioid receptor antagonist P. S. Portoghese, M. Sultana, and A. E. Takemori pp 1547 - 1548; DOI: 10.1021/jm00168a004 |
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DNA binding by antitumor anthracene derivatives Timothy P. Wunz, Mary T. Craven, Michael D. Karol, G. Craig Hill, and William A. Remers pp 1549 - 1553; DOI: 10.1021/jm00168a005 |
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Synthesis and structure-activity relationships of 6-substituted 2',3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents Chung K. Chu, Giliyar V. Ullas, Lak S. Jeong, Soon K. Ahn, Bogdan Doboszewski, Zhi X. Lin, J. Warren Beach, and Raymond F. Schinazi pp 1553 - 1561; DOI: 10.1021/jm00168a006 |
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Synthesis and bioactivity of a new class of rigid glutamate analogs. Modulators of the N-methyl-D-aspartate receptor Alan P. Kozikowski, Werner Tuckmantel, Ian J. Reynolds, and Jarda T. Wroblewski pp 1561 - 1571; DOI: 10.1021/jm00168a007 |
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Synthesis, metabolism, and pharmacological activity of 3.alpha.-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes Robert H. Purdy, A. Leslie Morrow, James R. Blinn, and Steven M. Paul pp 1572 - 1581; DOI: 10.1021/jm00168a008 |
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Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site Saul H. Rosenberg, Joseph F. Dellaria, Dale J. Kempf, Charles W. Hutchins, Keith W. Woods, Robert G. Maki, Ed De Lara, Kenneth P. Spina, Herman H. Stein, and et al. pp 1582 - 1590; DOI: 10.1021/jm00168a009 |
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Conformationally constrained congeners of 6-aryl-5-methyl-4,5-dihydro-3(2H)-pyridazinones active on the cardiovascular system: conformational studies by molecular mechanics calculations and proton NMR spectroscopy Lucio Toma, Giorgio Cignarella, Daniela Barlocco, and Fiamma Ronchetti pp 1591 - 1594; DOI: 10.1021/jm00168a010 |
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Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site Marcel F. Hibert, Remy Hoffmann, Robert C. Miller, and Albert A. Carr pp 1594 - 1600; DOI: 10.1021/jm00168a011 |
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Angiotensin converting enzyme inhibitors. 9. Novel [[N-(1-carboxyl-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity Jeffrey N. Barton, John J. Piwinski, Jerry W. Skiles, John R. Regan, Paul R. Menard, Rohit Desai, F. S. Golec, Laurence W. Reilly, Thomas Goetzen, and et al. pp 1600 - 1606; DOI: 10.1021/jm00168a012 |
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Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives James J. Mencel, John R. Regan, Jeffrey Barton, Paul R. Menard, Joseph G. Bruno, Raul R. Calvo, Brian E. Kornberg, Alfred Schwab, Edward S. Neiss, and John T. Suh pp 1606 - 1615; DOI: 10.1021/jm00168a013 |
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Structural study of the N-terminal segment of neuropeptide tyrosine Mylene Forest, Jean Claude Martel, Serge St-Pierre, Remi Quirion, and Alain Fournier pp 1615 - 1619; DOI: 10.1021/jm00168a014 |
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O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism Guillermo Tous, Andrew Bush, Ana Tous, and Frank Jordan pp 1620 - 1634; DOI: 10.1021/jm00168a015 |
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Structure-activity relationships of the lissoclinamides: cytotoxic cyclic peptides from the ascidian Lissoclinum patella Clifford J. Hawkins, Martin F. Lavin, Karen A. Marshall, Anna L. Van den Brenk, and Diane J. Watters pp 1634 - 1638; DOI: 10.1021/jm00168a016 |
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Oligosaccharide mapping of low-molecular-weight heparins: structure and activity differences Robert J. Linhardt, Duraikkannu Loganathan, Ali Al-Hakim, Hui Ming Wang, Jeanine M. Walenga, Debra Hoppensteadt, and Jawed Fareed pp 1639 - 1645; DOI: 10.1021/jm00168a017 |
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Pyridonecarboxylic acids as antibacterial agents. Part 14. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency Teruyuki Miyamoto, Junichi Matsumoto, Katsumi Chiba, Hiroshi Egawa, Kohichiro Shibamori, Akira Minamida, Yoshiro Nishimura, Hidetsugu Okada, Masahiro Kataoka, and et al. pp 1645 - 1656; DOI: 10.1021/jm00168a018 |
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Comparative reactivity of 1-carba-1-dethiacephalosporins with cephalosporins Larry C. Blaszczak, Raymond F. Brown, Gwendolyn K. Cook, William J. Hornback, Joseph M. Indelicato, Chris L. Jordan, Alan S. Katner, Michael D. Kinnick, John H. McDonald, III, and et al. pp 1656 - 1662; DOI: 10.1021/jm00168a019 |
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Nucleosides. 154. 2'-Azido-2',3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus James A. Warshaw and Kyoichi A. Watanabe pp 1663 - 1666; DOI: 10.1021/jm00168a020 |
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Vinylogous carbinolamine tumor inhibitors. 24. Synthesis, chemistry, and antineoplastic activity of .alpha.-halopyridinium salts: potential pyridone prodrugs of acylated vinylogous carbinolamine tumor inhibitors. Wayne K. Anderson, Dennis C. Dean, and Toshiyasu Endo pp 1667 - 1675; DOI: 10.1021/jm00168a021 |
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High-potency dipeptide sweeteners. 2. L-Aspartylfuryl-, thienyl-, and imidazolylglycine esters John M. Janusz, P. A. Young, R. B. Blum, and C. M. Riley pp 1676 - 1682; DOI: 10.1021/jm00168a022 |
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Synthesis and cytotoxicity of deoxyadenosine analogs: isomer distribution in the sodium salt glycosylation of 2,6-disubstituted purines Zygmunt Kazimierczuk, Juhani Vilpo, Catherine Hildebrand, and George Wright pp 1683 - 1687; DOI: 10.1021/jm00168a023 |
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Cardiotonic agents. 6. Histamine analogs as potential cardiovascular selective H2 agonists John W. Lampe, Reda G. Hanna, Thomas A. Piscitelli, Yuo Ling Chou, Paul W. Erhardt, William C. Lumma, Stanley S. Greenberg, William R. Ingebretsen, Dennis C. Marshall, and Jay Wiggins pp 1688 - 1697; DOI: 10.1021/jm00168a024 |
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Inhibition of vertebrate squalene epoxidase by extended and truncated analogs of trisnorsqualene alcohol Stephanie E. Sen, Czeslaw Wawrzenczyk, and Glenn D. Prestwich pp 1698 - 1701; DOI: 10.1021/jm00168a025 |
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All atom molecular mechanics simulations on covalent complexes of anthramycin and neothramycin with deoxydecanucleotides Shashidhar N. Rao and William A. Remers pp 1701 - 1707; DOI: 10.1021/jm00168a026 |
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A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic properties Philip J. M. Van Galen, Herman W. T. Van Vlijmen, Adriaan P. IJzerman, and Willem Soudijn pp 1708 - 1713; DOI: 10.1021/jm00168a027 |
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Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept P. S. Portoghese, M. Sultana, and A. E. Takemori pp 1714 - 1720; DOI: 10.1021/jm00168a028 |
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Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization Jack B. Jiang, D. P. Hesson, B. A. Dusak, D. L. Dexter, G. J. Kang, and E. Hamel pp 1721 - 1728; DOI: 10.1021/jm00168a029 |
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Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H Sandor Bajusz, Erzsebet Szell, Daniel Bagdy, Eva Barabas, Gyula Horvath, Marianne Dioszegi, Zsuzsa Fittler, Gabriella Szabo, Attila Juhasz, and et al. pp 1729 - 1735; DOI: 10.1021/jm00168a030 |
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1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene analogs: potent phosphodiesterase inhibitors and inodilators William J. Coates, H. Douglas Prain, Martin L. Reeves, and Brian H. Warrington pp 1735 - 1741; DOI: 10.1021/jm00168a031 |
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9,11-Epoxy-9-homoprosta-5-enoic acid analogs as thromboxane A2 receptor antagonists Jagabandhu Das, Steven E. Hall, Masami Nakane, Martin F. Haslanger, Joyce A. Reid, Dianne Garber, Vu Chi Truc, Don N. Harris, Anders Hedberg, and Martin L. Ogletree pp 1741 - 1748; DOI: 10.1021/jm00168a032 |
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Novel 3-hydroxy-2(1H)-pyridinones. Synthesis, iron(III)-chelating properties and biological activity Michael Streater, Paul D. Taylor, Robert C. Hider, and John Porter pp 1749 - 1755; DOI: 10.1021/jm00168a033 |
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Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist William K. Brewster, David E. Nichols, Robert M. Riggs, David M. Mottola, Timothy W. Lovenberg, Mark H. Lewis, and Richard B. Mailman pp 1756 - 1764; DOI: 10.1021/jm00168a034 |
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Structure-activity relationships for metal-labeled blood flow tracers: comparison of keto aldehyde bis(thiosemicarbazonato)copper(II) derivatives Elizabeth K. John and Mark A. Green pp 1764 - 1770; DOI: 10.1021/jm00168a035 |
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Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles Frederick J. Brown, Ying K. Yee, Laura A. Cronk, Kevin C. Hebbel, Robert D. Krell, and David W. Snyder pp 1771 - 1781; DOI: 10.1021/jm00168a036 |
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Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles Victor G. Matassa, Thomas P. Maduskuie, Howard S. Shapiro, Barrie Hesp, David W. Snyder, David Aharony, Robert D. Krell, and Richard A. Keith pp 1781 - 1790; DOI: 10.1021/jm00168a037 |
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Substituted vitamin K epoxide analogs. New competitive inhibitors and substrates of vitamin K1 epoxide reductase Robert P. Ryall, Dhirendra L. Nandi, and Richard B. Silverman pp 1790 - 1797; DOI: 10.1021/jm00168a038 |
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Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine Choung Un Kim, Bing Yu Luh, and John C. Martin pp 1797 - 1800; DOI: 10.1021/jm00168a039 |
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Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogs Yigong Gao, Ross J. Baldessarini, Nora S. Kula, and John L. Neumeyer pp 1800 - 1805; DOI: 10.1021/jm00168a040 |
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Long-acting dihydropyridine calcium antagonists. 5. Synthesis and structure-activity relationships for a series of 2-[[(N-substituted-heterocyclyl)ethoxy]methyl]-1,4-dihydropyridine calcium antagonists David Alker, Simon F. Campbell, Peter E. Cross, Roger A. Burges, Anthony J. Carter, and Donald G. Gardiner pp 1805 - 1811; DOI: 10.1021/jm00168a041 |
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Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties Susan L. Morris-Natschke, Karen L. Meyer, Canio J. Marasco, Claude Piantadosi, Fiona Rossi, Patrick L. Godwin, and Edward J. Modest pp 1812 - 1818; DOI: 10.1021/jm00168a042 |
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Syntheses and platelet aggregation inhibitory and antithrombotic properties of [2-[(.omega.-Aminoalkoxy)phenyl]benzenes Ryoji Kikumoto, Hiroto Hara, Kunihiro Ninomiya, Masanori Osakabe, Mamoru Sugano, Harukazu Fukami, and Yoshikuni Tamao pp 1818 - 1823; DOI: 10.1021/jm00168a043 |
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The synthesis and antiallergy activity of 1-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives David A. Walsh, Ying Ho Chen, Jerry B. Green, Joseph C. Nolan, and John M. Yanni pp 1823 - 1827; DOI: 10.1021/jm00168a044 |
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Synthesis and biological evaluation of analogs of Pro-Leu-Gly-NH2 modified at the leucyl residue Rodney L. Johnson, Roger J. Bontems, Kaipeen E. Yang, and Ram K. Mishra pp 1828 - 1832; DOI: 10.1021/jm00168a045 |
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Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogs: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides Arthur Van Aerschot, Dirk Everaert, Jan Balzarini, Koen Augustyns, Liu Jie, Gerard Janssen, Oswald Peeters, Norbert Blaton, Camiel De Ranter, and et al. pp 1833 - 1839; DOI: 10.1021/jm00168a046 |
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Book Reviews pp 1840 - 1842; DOI: 10.1021/jm00168a600 |
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Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications Roger M. Freidinger, P. D. Williams, R. D. Tung, M. G. Bock, D. J. Pettibone, B. V. Clineschmidt, R. M. DiPardo, J. M. Erb, V. M. Garsky, and et al. pp 1843 - 1845; DOI: 10.1021/jm00169a001 |
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Vinblastine and vincristine are inhibitors of monoamine oxidase B Jong Keun Son, John P. N. Rosazza, and Michael W. Duffel pp 1845 - 1848; DOI: 10.1021/jm00169a002 |
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Potent and highly selective neurokinin antagonists P. Ward, G. B. Ewan, C. C. Jordan, S. J. Ireland, R. M. Hagan, and J. R. Brown pp 1848 - 1851; DOI: 10.1021/jm00169a003 |
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Synthesis and antiinflammatory activity of novel 12.beta.-substituted analogs of betamethasone Mitchell A. Avery, George Detre, Dennis Yasuda, Wan Ru Chao, Masato Tanabe, David Crowe, Richard Peters, and Wesley K. M. Chong pp 1852 - 1858; DOI: 10.1021/jm00169a004 |
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Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones Reinhard Sarges, Steven W. Goldstein, Willard M. Welch, Archie C. Swindell, Todd W. Siegel, and Thomas A. Beyer pp 1859 - 1865; DOI: 10.1021/jm00169a005 |
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1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine .beta.-hydroxylase James R. McCarthy, Donald P. Matthews, Robert J. Broersma, Roger D. McDermott, Philip R. Kastner, Jean Marie Hornsperger, David A. Demeter, Herschel J. R. Weintraub, and Jeffrey P. Whitten pp 1866 - 1873; DOI: 10.1021/jm00169a006 |
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Design and synthesis of highly potent and selective cyclic dynorphin A analogs Andrew M. Kawasaki, Richard J. Knapp, Thomas H. Kramer, William S. Wire, Olga S. Vasquez, Henry I. Yamamura, Thomas F. Burks, and Victor J. Hruby pp 1874 - 1879; DOI: 10.1021/jm00169a007 |
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Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives Hachiro Sugimoto, Yutaka Tsuchiya, Hiroyuki Sugumi, Kunizo Higurashi, Norio Karibe, Yoichi Iimura, Atsushi Sasaki, Yoshiyuki Kawakami, Takaharu Nakamura, and et al. pp 1880 - 1887; DOI: 10.1021/jm00169a008 |
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Synthesis of (3'R,5'S)-trans-3'-hydroxycotinine, a major metabolite of nicotine. Metabolic formation of 3'-hydroxycotinine in humans is highly stereoselective Peyton Jacob, Alexander T. Shulgin, and Neal L. Benowitz pp 1888 - 1891; DOI: 10.1021/jm00169a009 |
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Effect of structure on potency and selectivity in 2,6-disubstituted-4-(2-arylethenyl)phenol lipoxygenase inhibitors Edward S. Lazer, Hin Chor Wong, Craig D. Wegner, Anne G. Graham, and Peter R. Farina pp 1892 - 1898; DOI: 10.1021/jm00169a010 |
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Synthesis and calcium ion antagonistic activity of 2-[2-[(aminoalkyl)oxy]-5-methoxyphenyl]-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazines Masanobu Fujita, Susumu Ito, Atsutoshi Ota, Nobuharu Kato, Koji Yamamoto, Yoichi Kawashima, Hideyasu Yamauchi, and Junichi Iwao pp 1898 - 1905; DOI: 10.1021/jm00169a011 |
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Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors T. Katsushima, L. Nieves, and J. N. Wells pp 1906 - 1910; DOI: 10.1021/jm00169a012 |
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Benzodiazepine receptor-binding activity of 9-(1-phenylethyl)purines James L. Kelley, Ed W. McLean, Robert M. Ferris, and James L. Howard pp 1910 - 1914; DOI: 10.1021/jm00169a013 |
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Structure-activity relationships of antineoplastic agents in multidrug resistance Cynthia D. Selassie, Corwin Hansch, and Tasneem A. Khwaja pp 1914 - 1919; DOI: 10.1021/jm00169a014 |
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2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands Alan J. Hutchison, Michael Williams, Reynalda De Jesus, Rina Yokoyama, Howard H. Oei, Geetha R. Ghai, Randy L. Webb, Harry C. Zoganas, George A. Stone, and Michael F. Jarvis pp 1919 - 1924; DOI: 10.1021/jm00169a015 |
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5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives Jose Bermudez, Charles S. Fake, Graham F. Joiner, Karen A. Joiner, Frank D. King, Wesley D. Miner, and Gareth J. Sanger pp 1924 - 1929; DOI: 10.1021/jm00169a016 |
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5-Hydroxytryptamine (5-HT3) receptor antagonists. 2. 1-Indolinecarboxamides Jose Bermudez, Steven Dabbs, Karen A. Joiner, and Frank D. King pp 1929 - 1932; DOI: 10.1021/jm00169a017 |
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5-Hydroxytryptamine (5-HT3) receptor antagonists. 3. Ortho-substituted phenylureas Jose Bermudez, Steven Dabbs, and Frank D. King pp 1932 - 1935; DOI: 10.1021/jm00169a018 |
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Conformational restriction of angiotensin II: cyclic analogs having high potency Kerry L. Spear, Monica S. Brown, Emily J. Reinhard, Ellen G. McMahon, Gillian M. Olins, Maria A. Palomo, and Dennis R. Patton pp 1935 - 1940; DOI: 10.1021/jm00169a019 |
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Crystallographic studies of angiotensin converting enzyme inhibitors and analysis of preferred zinc coordination geometry Roland J. Hausin and Penelope W. Codding pp 1940 - 1947; DOI: 10.1021/jm00169a020 |
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Chalcones: a new class of antimitotic agents Michael L. Edwards, David M. Stemerick, and Prasad S. Sunkara pp 1948 - 1954; DOI: 10.1021/jm00169a021 |
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Analogs of growth hormone-releasing factor (1-29) amide containing the reduced peptide bond isostere in the N-terminal region Simon J. Hocart, William A. Murphy, and David H. Coy pp 1954 - 1958; DOI: 10.1021/jm00169a022 |
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Cyclohexane diester analogs of phorbol ester as potential activators of protein kinase C David E. Kerr, Lon F. Kissinger, and Mohammed Shoyab pp 1958 - 1962; DOI: 10.1021/jm00169a023 |
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Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action Saul H. Rosenberg, Keith W. Woods, Hing L. Sham, Hollis D. Kleinert, Donald L. Martin, Herman Stein, Jerome Cohen, David A. Egan, Barbara Bopp, and et al. pp 1962 - 1969; DOI: 10.1021/jm00169a024 |
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Inhibition of ornithine decarboxylase by the isomers of 1,4-dimethylputrescine Nora Moyano, Judith Frydman, Graciela Buldain, Oscar Ruiz, and Rosalia B. Frydman pp 1969 - 1974; DOI: 10.1021/jm00169a025 |
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Synthesis and biological activities of novel 5-(2-acylethynyl)uracils Nitya G. Kundu, Biswajit Das, C. Paul Spears, Anjali Majumdar, and San Ihn Kang pp 1975 - 1979; DOI: 10.1021/jm00169a026 |
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Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogs of sangivamycin and toyocamycin Naveen K. Saxena, Lisa A. Coleman, John C. Drach, and Leroy B. Townsend pp 1980 - 1983; DOI: 10.1021/jm00169a027 |
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Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines Jeffrey S. Pudlo, M. Reza Nassiri, Earl R. Kern, Linda L. Wotring, John C. Drach, and Leroy B. Townsend pp 1984 - 1992; DOI: 10.1021/jm00169a028 |
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Synthesis and antiviral activity of metabolites of rimantadine Percy S. Manchand, Richard L. Cerruti, Joseph A. Martin, Christopher H. Hill, John H. Merrett, Elizabeth Keech, Robert B. Belshe, Edward V. Connell, and Iain S. Sim pp 1992 - 1995; DOI: 10.1021/jm00169a029 |
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Nucleosides. 153. Synthesis of 1-methyl-5-(3-azido-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl)uracil and 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-.beta.-D-arabinofuranosyl)uracil. The C-nucleoside isostere of 3'-azido-3'-deoxythymidine and its 2'-"up"-fluoro analog Elzbieta Sochacka, Barbara Nawrot, Krzysztof W. Pankiewicz, and Kyoichi A. Watanabe pp 1995 - 1999; DOI: 10.1021/jm00169a030 |
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Monomethyl ether derivatives of 7,8-dihydroxy- and 8,9-dihydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines as possible products of metabolism by catechol-O-methyltransferase Joseph G. Cannon, Kathleen A. Walker, Antonio Montanari, John Paul Long, and Jan R. Flynn pp 2000 - 2006; DOI: 10.1021/jm00169a031 |
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Synthesis, antitumor activity, and antiviral activity of 3-substituted 3-deazacytidines and 3-substituted 3-deazauridines Dennis J. McNamara, P. Dan Cook, Lois B. Allen, Mary Jo Kehoe, Carolyn S. Holland, and Annette G. Teepe pp 2006 - 2011; DOI: 10.1021/jm00169a032 |
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Synthesis and antibacterial activity of thiazolo-, oxazolo-, and imidazolo[3,2-a][1,8]naphthyridinecarboxylic acids Hirosato Kondo, Masahiro Taguchi, Yoshimasa Inoue, Fumio Sakamoto, and Goro Tsukamoto pp 2012 - 2015; DOI: 10.1021/jm00169a033 |
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Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl, (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and PET studies in baboon brain Alain Plenevaux, Stephen L. Dewey, Joanna S. Fowler, Marcel Guillaume, and Alfred P. Wolf pp 2015 - 2019; DOI: 10.1021/jm00169a034 |
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1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with anti-inflammatory activity Banavara L. Mylari, Thomas J. Carty, Peter F. Moore, and William J. Zembrowski pp 2019 - 2024; DOI: 10.1021/jm00169a035 |
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Synthesis of 3-arylecgonine analogs as inhibitors of cocaine binding and dopamine uptake Richard H. Kline, Jeremy Wright, Kristine M. Fox, and Mohyee E. Eldefrawi pp 2024 - 2027; DOI: 10.1021/jm00169a036 |
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Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives David A. Walsh, Jerry B. Green, Stephen K. Franzyshen, Joseph C. Nolan, and John M. Yanni pp 2028 - 2032; DOI: 10.1021/jm00169a037 |
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Porphyrin dimers as photosensitizers in photodynamic therapy Ravindra K. Pandey, Kevin M. Smith, and Thomas J. Dougherty pp 2032 - 2038; DOI: 10.1021/jm00169a038 |
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Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA intercalating agents which bind by threading through the DNA helix Laurence P. G. Wakelin, Pat Chetcuti, and William A. Denny pp 2039 - 2044; DOI: 10.1021/jm00169a039 |
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Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines Dennis J. McNamara, Ellen M. Berman, David W. Fry, and Leslie M. Werbel pp 2045 - 2051; DOI: 10.1021/jm00169a040 |
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Synthesis and muscarinic activities of 1,2,4-thiadiazoles Angus M. MacLeod, Raymond Baker, Stephen B. Freedman, Shailendra Patel, Kevin J. Merchant, Michael Roe, and John Saunders pp 2052 - 2059; DOI: 10.1021/jm00169a041 |
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Book Reviews pp 2059 - 2062; DOI: 10.1021/jm00169a600 |
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Improved delivery through biological membranes. 36. Extension of a redox-based chemical-delivery system to .alpha.,.beta.-unsaturated ketones Marcus E. Brewster, Margaret Deyrup, Klara Czako, and Nicholas Bodor pp 2063 - 2065; DOI: 10.1021/jm00170a001 |
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A radiotracer for mapping cholinergic neurons of the brain Yong Woon Jung, Marcian E. Van Dort, David L. Gildersleeve, and Donald M. Wieland pp 2065 - 2068; DOI: 10.1021/jm00170a002 |
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Methylsulfamic acid esters. A new chemical class of oral antiarthritic agents David A. Walsh, Young S. Lo, Dwight A. Shamblee, William J. Welstead, Joseph C. Nolan, and Gustav Graff pp 2068 - 2070; DOI: 10.1021/jm00170a003 |
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Nonsteroidal anti-inflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase Daniel L. Flynn, Thomas Capiris, W. J. Cetenko, David T. Connor, Richard D. Dyer, Catherine R. Kostlan, Donald E. Nies, Denis J. Schrier, and Jagadish C. Sircar pp 2070 - 2072; DOI: 10.1021/jm00170a004 |
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Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase Rodney C. Young, Martin Jones, Kevin J. Milliner, Kishore K. Rana, and John G. Ward pp 2073 - 2080; DOI: 10.1021/jm00170a005 |
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Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin D. E. Epps, J. Cheney, H. Schostarez, T. K. Sawyer, M. Prairie, W. C. Krueger, and F. Mandel pp 2080 - 2086; DOI: 10.1021/jm00170a006 |
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3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1*) agonist and rotationally restricted phenolic analog of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole John E. Macor, Carol A. Burkhart, James H. Heym, Jeffrey L. Ives, Lorraine A. Lebel, Michael E. Newman, Jann A. Nielsen, Kevin Ryan, David W. Schulz, and et al. pp 2087 - 2093; DOI: 10.1021/jm00170a007 |
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Antiandrogenic steroidal sulfonylpyrazoles Robert G. Christiansen, Malcolm R. Bell, Thomas E. D'Ambra, John P. Mallamo, John L. Herrmann, James H. Ackerman, Chester J. Opalka, Rudolph K. Kullnig, Richard C. Winneker, and et al. pp 2094 - 2100; DOI: 10.1021/jm00170a008 |
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Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists Marco Turconi, Massimo Nicola, Myrna Gil Quintero, Luciano Maiocchi, Rosella Micheletti, Ettore Giraldo, and Arturo Donetti pp 2101 - 2108; DOI: 10.1021/jm00170a009 |
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Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads Enzo Cereda, Antoine Ezhaya, Myrna Gil Quintero, Elio Bellora, Enrica Dubini, Rosella Micheletti, Antonio Schiavone, Alessandro Brambilla, Giovanni Battista Schiavi, and Arturo Donetti pp 2108 - 2113; DOI: 10.1021/jm00170a010 |
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Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins Raymond F. Brown, Michael D. Kinnick, John M. Morin Jr., Robert T. Vasileff, Fred T. Counter, Edward O. Davidson, Paul W. Ensminger, Judith A. Eudaly, Jeffrey S. Kasher, and et al. pp 2114 - 2121; DOI: 10.1021/jm00170a011 |
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Synthesis and activity of NAcSerAspLysPro analogs on cellular interactions between T-cell and erythrocytes in rosette formation Josiane Thierry, Marie Pierre Papet, Nathalie Saez-Servent, Jacqueline Plissonneau-Haumont, Pierre Potier, and Maryse Lenfant pp 2122 - 2127; DOI: 10.1021/jm00170a012 |
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Synthesis and broad-spectrum antiviral activity of 7,8-dihydro-7-methyl-8-thioxoguanosine Elizabeth M. Henry, Ganesh D. Kini, Steven B. Larson, Roland K. Robins, Hassan A. Alaghamandan, and Donald F. Smee pp 2127 - 2130; DOI: 10.1021/jm00170a013 |
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Synthesis and central nervous system actions of thyrotropin-releasing hormone analog containing a dihydroorotic acid moiety Mamoru Suzuki, Hiroshi Sugano, Kazuo Matsumoto, Michio Yamamura, and Ryuichi Ishida pp 2130 - 2137; DOI: 10.1021/jm00170a014 |
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Synthesis and antiviral activity of monofluoro and difluoro analogs of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1) Joseph A. Martin, David J. Bushnell, Ian B. Duncan, Stephen J. Dunsdon, Michael J. Hall, Peter J. Machin, John H. Merrett, Kevin E. B. Parkes, Noel A. Roberts, and et al. pp 2137 - 2145; DOI: 10.1021/jm00170a015 |
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Synthesis and anti-HIV-1 activity of 2'-"up"-fluoro analogs of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC) Kyoichi A. Watanabe, Kazuho Harada, Joanna Zeidler, Jasenka Matulic-Adamic, Kiyobumi Takahashi, Wu Yun Ren, Ling Chin Cheng, Jack J. Fox, Ting Chao Chou, and et al. pp 2145 - 2150; DOI: 10.1021/jm00170a016 |
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Synthesis and anti-HIV activity of several 2'-fluoro-containing pyrimidine nucleosides Roman Z. Sterzycki, Ismail Ghazzouli, Vera Brankovan, John C. Martin, and Muzammil M. Mansuri pp 2150 - 2157; DOI: 10.1021/jm00170a017 |
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2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid. A potent irreversible inhibitor of diaminopimelic acid epimerase. Spontaneous formation from .alpha.-(halomethyl)diaminopimelic acids Fritz Gerhart, William Higgins, Chantal Tardif, and Jean Bernard Ducep pp 2157 - 2162; DOI: 10.1021/jm00170a018 |
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Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs Sharon M. Bennett, Nguyen Ba Nghe, and Kelvin K. Ogilvie pp 2162 - 2173; DOI: 10.1021/jm00170a019 |
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Guanosine analogs. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents Roger J. Bontems, Jack D. Anderson, Donald F. Smee, Ai Jin, Hassan A. Alaghamandan, Brahma S. Sharma, Weldon B. Jolley, Roland K. Robins, and Howard B. Cottam pp 2174 - 2178; DOI: 10.1021/jm00170a020 |
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Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes Nicholas Farrell, Yun Qu, and Miles P. Hacker pp 2179 - 2184; DOI: 10.1021/jm00170a021 |
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Antitumor and DNA-binding properties of a group of oligomeric complexes of platinum(II) and platinum(IV) Adam Peritz, Salaam Al-Baker, Jean F. Vollano, James C. Dabrowiak, John E. Schurig, and William T. Bradner pp 2184 - 2188; DOI: 10.1021/jm00170a022 |
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Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine C. K. Chu, V. S. Bhadti, K. J. Doshi, J. T. Etse, J. M. Gallo, F. D. Boudinot, and R. F. Schinazi pp 2188 - 2192; DOI: 10.1021/jm00170a023 |
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Organic phosphorus compounds. 5. (4-Benzothiazol-2-ylbenzyl)amidophosphonate as potent calcium antagonistic vasodilators Kohichiro Yoshino, Katsumi Goto, Kazuya Yoshiizumi, Tominori Morita, and Goro Tsukamoto pp 2192 - 2196; DOI: 10.1021/jm00170a024 |
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Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series Ingrid Pettersson, Tommy Liljefors, and Klaus Boegesoe pp 2197 - 2204; DOI: 10.1021/jm00170a025 |
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Synthesis and biological evaluation of 4-fluoro-, 7-fluoro-, and 4,7-difluoro-5,6-dihydroxytryptamines Masami Kawase, Achintya K. Sinhababu, Eva M. McGhee, Terry Milby, and Ronald T. Borchardt pp 2204 - 2211; DOI: 10.1021/jm00170a026 |
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Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines Andrew Thurkauf, Brian De Costa, Mariena V. Mattson, Charles P. France, Madelon T. Price, John W. Olney, James H. Woods, A. E. Jacobson, and Kenner C. Rice pp 2211 - 2215; DOI: 10.1021/jm00170a027 |
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Improved delivery through biological membranes. 50. Antihypertensive activity of redox derivatives of tryptophan Emil Pop, Wesley Anderson, Katalin Prokai-Tatrai, Marcus E. Brewster, Melvin Fregly, and Nicholas Bodor pp 2216 - 2221; DOI: 10.1021/jm00170a028 |
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In vivo intracerebral microdialysis studies in rats of MPP+ (1-methyl-4-phenylpyridinium) analogs and related charged species Hans Rollema, E. Anne Johnson, Raymond G. Booth, Patricia Caldera, Peter Lampen, Stephen K. Youngster, Anthony J. Trevor, Noreen Naiman, and Neal Castagnoli pp 2221 - 2230; DOI: 10.1021/jm00170a029 |
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Inotropic 'A' ring substituted sulmazole and isomazole analogs Paul Barraclough, James W. Black, David Cambridge, David Collard, David Firmin, V. Paul Gerskowitch, Robert C. Glen, Heather Giles, Alan P. Hill, and et al. pp 2231 - 2239; DOI: 10.1021/jm00170a030 |
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4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants Reinhard Sarges, Harry R. Howard, Ronald G. Browne, Lorraine A. Lebel, Patricia A. Seymour, and B. Kenneth Koe pp 2240 - 2254; DOI: 10.1021/jm00170a031 |
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4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies N. R. Natale, David J. Triggle, Robert B. Palmer, Barbara J. Lefler, and W. Daniel Edwards pp 2255 - 2259; DOI: 10.1021/jm00170a032 |
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Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents Krishnamurthy Shyam, Philip G. Penketh, Alan A. Divo, Regina H. Loomis, Curtis L. Patton, and Alan C. Sartorelli pp 2259 - 2264; DOI: 10.1021/jm00170a033 |
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Monophosphoric acid diesters of 7.beta.-hydroxycholesterol and of pyrimidine nucleosides as potential antitumor agents: synthesis and preliminary evaluation of antitumor activity Yu Hua Ji, Christiane Moog, Gaby Schmitt, Pierre Bischoff, and Bang Luu pp 2264 - 2270; DOI: 10.1021/jm00170a034 |
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Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships Townley P. Culbertson, Joseph P. Sanchez, Laura Gambino, and Josephine A. Sesnie pp 2270 - 2275; DOI: 10.1021/jm00170a035 |
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Potent renin inhibitory peptides containing hydrophilic end groups Gordon L. Bundy, Donald T. Pals, Judy A. Lawson, Sally J. Couch, Michael F. Lipton, and Michael A. Mauragis pp 2276 - 2283; DOI: 10.1021/jm00170a036 |
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Resolution, absolute stereochemistry, and enantioselectivity of 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-4-ol Masaru Kihara, Minoru Kashimoto, Shigeru Kobayashi, Yukio Ishida, Hideki Moritoki, and Zenei Taira pp 2283 - 2286; DOI: 10.1021/jm00170a037 |
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Electrophilic .alpha.-methylene-.gamma.-lactone and isothiocyanate opioid ligands related to etorphine Peter Klein, Wendel L. Nelson, Yi He Yao, and Eric J. Simon pp 2286 - 2296; DOI: 10.1021/jm00170a038 |
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Antiinflammatory agents. 4. Syntheses and biological evaluation of potential pro-drugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid David A. Walsh, H. Wayne Moran, Dwight A. Shamblee, William J. Welstead, Joseph C. Nolan, Lawrence F. Sancilio, and Gustav Graff pp 2296 - 2304; DOI: 10.1021/jm00170a039 |
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Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study Thomas Hoegberg, Tomas De Paulis, Lars Johansson, Yatendra Kumar, Haakan Hall, and Sven Ove Oegren pp 2305 - 2309; DOI: 10.1021/jm00170a040 |
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Book Reviews pp 2310 - 2310; DOI: 10.1021/jm00170a600 |
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Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine Arnold Brossi pp 2311 - 2319; DOI: 10.1021/jm00171a001 |
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Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secoestradiol Saurabh S. Lawate and Douglas F. Covey pp 2319 - 2321; DOI: 10.1021/jm00171a002 |
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Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide Mark G. Bock, R. M. DiPardo, P. D. Williams, D. J. Pettibone, B. V. Clineschmidt, R. G. Ball, D. F. Veber, and R. M. Freidinger pp 2321 - 2323; DOI: 10.1021/jm00171a003 |
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Azulene derivatives: new non-prostanoid thromboxane A2 receptor antagonists Tsuyoshi Tomiyama, Shuichi Wakabayashi, Kazuhiro Kosakai, and Masayuki Yokota pp 2323 - 2326; DOI: 10.1021/jm00171a004 |
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1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 1. Synthesis and biological properties of alkyl alcohol and statine derivatives David A. Roberts, Robert H. Bradbury, David Brown, Alan Faull, David Griffiths, John S. Major, Alec A. Oldham, Robert J. Pearce, Arnold H. Ratcliffe, and et al. pp 2326 - 2334; DOI: 10.1021/jm00171a005 |
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1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 2. Synthesis, biological properties and molecular modeling of hydroxyethylene isostere derivatives Robert H. Bradbury, John S. Major, Alec A. Oldham, Janet E. Rivett, David A. Roberts, Anthony M. Slater, David Timms, and David Waterson pp 2335 - 2342; DOI: 10.1021/jm00171a006 |
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Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site Michael S. Allen, Yun C. Tan, Mark L. Trudell, Kris Narayanan, Liesl R. Schindler, Michael J. Martin, Christopher Schultz, Timothy J. Hagen, Konrad F. Koehler, and et al. pp 2343 - 2357; DOI: 10.1021/jm00171a007 |
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Synthesis and quantitative structure-activity relationships of diclofenac analogs Peter Moser, Alfred Sallmann, and Irmgard Wiesenberg pp 2358 - 2368; DOI: 10.1021/jm00171a008 |
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Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives A. Kumar, P. L. Coe, A. S. Jones, R. T. Walker, J. Balzarini, and Eric De Clercq pp 2368 - 2375; DOI: 10.1021/jm00171a009 |
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Synthesis and antitumor activity of novel 4-demethoxyanthracyclines Nigel Adams, Colin Blake, Michael J. Broadhurst, David J. Bushnell, Cedric H. Hassall, Hans R. Hartmann, Elizabeth Keech, Alan R. Stratton, and Gareth J. Thomas pp 2375 - 2379; DOI: 10.1021/jm00171a010 |
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Synthesis and antitumor activity of 9-[(carbamoyloxy)alkyl]anthracyclines a novel class of anthracycline derivatives Nigel Adams, Colin Blake, Michael J. Broadhurst, David J. Bushnell, Cedric H. Hassall, Hans R. Hartmann, Elizabeth Keech, Alan R. Stratton, and Gareth J. Thomas pp 2380 - 2384; DOI: 10.1021/jm00171a011 |
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[(1-Pyrenylmethyl)amino] alcohols, a new class of antitumor DNA intercalators. Discovery and initial amine side chain structure-activity studies Kenneth W. Bair, Richard L. Tuttle, Vincent C. Knick, Michael Cory, and David D. McKee pp 2385 - 2393; DOI: 10.1021/jm00171a012 |
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Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships J. Jeffry Howbert, C. Sue Grossman, Thomas A. Crowell, Brent J. Rieder, Richard W. Harper, Kenneth E. Kramer, Eddie V. Tao, James Aikins, Gerald A. Poore, and et al. pp 2393 - 2407; DOI: 10.1021/jm00171a013 |
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Synthesis and dopamine receptor affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-substituted derivatives Francesco Claudi, Mario Cardellini, Gian Mario Cingolani, Alessandro Piergentili, Guidubaldo Peruzzi, and Walter Balduini pp 2408 - 2412; DOI: 10.1021/jm00171a014 |
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Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties Mark L. Trudell, Sherry L. Lifer, Yun Chou Tan, Michael J. Martin, Li Deng, Phil Skolnick, and James M. Cook pp 2412 - 2420; DOI: 10.1021/jm00171a015 |
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Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogs, high-affinity ligands for the haloperidol-sensitive .sigma. receptor Michael W. Scherz, Michelle Fialeix, James B. Fischer, N. Laxma Reddy, Alfred C. Server, Mark S. Sonders, Barbara C. Tester, Eckard Weber, Scott T. Wong, and John F. W. Keana pp 2421 - 2429; DOI: 10.1021/jm00171a016 |
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N-Fluoroalkylated and N-alkylated analogs of the dopaminergic D-2 receptor antagonist raclopride G. S. Lannoye, Stephen M. Moerlein, D. Parkinson, and M. J. Welch pp 2430 - 2437; DOI: 10.1021/jm00171a017 |
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A novel series of selective leukotriene antagonists: exploration and optimization of the acidic region in 1,6-disubstituted indoles and indazoles Ying K. Yee, Peter R. Bernstein, Edward J. Adams, Frederick J. Brown, Laura A. Cronk, Kevin C. Hebbel, Edward P. Vacek, Robert D. Krell, and David W. Snyder pp 2437 - 2451; DOI: 10.1021/jm00171a018 |
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Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis Michael Jarman, S. Elaine Barrie, John J. Deadman, John Houghton, Raymond McCague, and Martin G. Rowlands pp 2452 - 2455; DOI: 10.1021/jm00171a019 |
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Photoactivatable opiate derivatives as irreversible probes of the .mu.-opioid receptor Jean Luc Galzi, Annick Mejean, Brigitte Ilien, Catherine Mollereau, Jean Claude Meunier, Maurice Goeldner, and Christian Hirth pp 2456 - 2464; DOI: 10.1021/jm00171a020 |
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7-Oxabicyclo[2.2.1]heptyl carboxylic acids as thromboxane A2 antagonists: aza .omega.-chain analogs Masami Nakane, Joyce A. Reid, Wen Ching Han, Jagabandhu Das, Vu Chi Truc, Martin F. Haslanger, Dianne Garber, Don N. Harris, Anders Hedberg, and et al. pp 2465 - 2476; DOI: 10.1021/jm00171a021 |
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Synthesis of new (.+-.)-3,5-dihydroxypentyl nucleoside analogs from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation Michel Legraverend, Hassane Boumchita, Aurelio Zerial, Christiane Huel, Marc Lemaitre, and Emile Bisagni pp 2476 - 2480; DOI: 10.1021/jm00171a022 |
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5'-O-Phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity Liu Jie, Arthur Van Aerschot, Jan Balzarini, Gerard Janssen, Roger Busson, Jos Hoogmartens, Erik De Clercq, and Piet Herdewijn pp 2481 - 2487; DOI: 10.1021/jm00171a023 |
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Synthesis and antiviral activity of some 3'-C-difluoromethyl- and 3'-deoxy-3'-C-fluoromethyl nucleosides Mark J. Bamford, Paul L. Coe, and Richard T. Walker pp 2488 - 2494; DOI: 10.1021/jm00171a024 |
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Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides Mark J. Bamford, Paul L. Coe, and Richard T. Walker pp 2494 - 2501; DOI: 10.1021/jm00171a025 |
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S-[2-[(2'-carbamoylethyl)amino]ethyl] phosphorothioate and related compounds as potential antiradiation agents F. Ivy Carroll, M. B. Gopinathan, and Abraham Philip pp 2501 - 2508; DOI: 10.1021/jm00171a026 |
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Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins Matthew A. Naylor, Miriam A. Stephens, Shirley Cole, Michael D. Threadgill, Ian J. Stratford, Peter O'Neill, E. Martin Fielden, and Gerald E. Adams pp 2508 - 2513; DOI: 10.1021/jm00171a027 |
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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters James B. Doherty, Bonnie M. Ashe, Peter L. Barker, Thomas J. Blacklock, John W. Butcher, Gilbert O. Chandler, M. Ellen Dahlgren, Philip Davies, Conrad P. Dorn Jr., and et al. pp 2513 - 2521; DOI: 10.1021/jm00171a028 |
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Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides Paul E. Finke, Bonnie M. Ashe, Wilson B. Knight, Alan L. Maycock, Manuel A. Navia, Shrenik K. Shah, Kevan R. Thompson, Dennis J. Underwood, Hazel Weston, and et al. pp 2522 - 2528; DOI: 10.1021/jm00171a029 |
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Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins Shrenik K. Shah, Karen A. Brause, Gilbert O. Chandler, Paul E. Finke, Bonnie M. Ashe, Hazel Weston, Wilson B. Knight, Alan L. Maycock, and James B. Doherty pp 2529 - 2535; DOI: 10.1021/jm00171a030 |
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Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties Ronald Gust, Thomas Burgemeister, Albrecht Mannschreck, and Helmut Schoenenberger pp 2535 - 2544; DOI: 10.1021/jm00171a031 |
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Approaches to isozyme-specific inhibitors. 17. Attachment of a selectivity-inducing substituent to a multisubstrate adduct. Implications for facilitated design of potent, isozyme-selective inhibitors Francis Kappler and Alexander Hampton pp 2545 - 2551; DOI: 10.1021/jm00171a032 |
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Novel inhibitors of human renin. Cyclic peptides based on the tetrapeptide sequence Glu-D-Phe-Lys-D-Trp Anand S. Dutta, James J. Gormley, Peter F. McLachlan, and John S. Major pp 2552 - 2560; DOI: 10.1021/jm00171a033 |
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Inhibitors of human renin. Cyclic peptide analogs containing a D-Phe-Lys-D-Trp sequence Anand S. Dutta, James J. Gormley, Peter F. McLachlan, and John S. Major pp 2560 - 2568; DOI: 10.1021/jm00171a034 |
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Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 2. The "A" group Walter A. Gregory, David R. Brittelli, C. L. J. Wang, Hollis S. Kezar, III, Randall K. Carlson, Chung Ho Park, Peter F. Corless, Steven J. Miller, P. Rajagopalan, and et al. pp 2569 - 2578; DOI: 10.1021/jm00171a035 |
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1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents R. H. Smith, D. A. Scudiero, and Christopher J. Michejda pp 2579 - 2583; DOI: 10.1021/jm00171a036 |
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Neural networks applied to pharmaceutical problems. III. Neural networks applied to quantitative structure-activity relationship (QSAR) analysis Tomoo Aoyama, Yuji Suzuki, and Hiroshi Ichikawa pp 2583 - 2590; DOI: 10.1021/jm00171a037 |
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Cyclization-activated prodrugs. Basic esters of 5-bromo-2'-deoxyuridine Walfred S. Saari, John E. Schwering, Paulette A. Lyle, Steven J. Smith, and Edward L. Engelhardt pp 2590 - 2595; DOI: 10.1021/jm00171a038 |
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Synthesis of new nucleoside phosphoraziridines as potential site-directed antineoplastic agents Robert G. Breiner, William C. Rose, Joseph A. Dunn, Joan E. MacDiarmid, and Thomas J. Bardos pp 2596 - 2602; DOI: 10.1021/jm00171a039 |
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Synthesis and evaluation of .alpha.-[[(2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of .alpha.-[(1-aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogs which are radiosensitizers and bioreductively activated cytotoxins Terence C. Jenkins, Matthew A. Naylor, Peter O'Neill, Michael D. Threadgill, Shirley Cole, Ian J. Stratford, Gerald E. Adams, E. Martin Fielden, Mark J. Suto, and Michael A. Stier pp 2603 - 2610; DOI: 10.1021/jm00171a040 |
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Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 3. Aromatic amine analogs Ai J. Lin, Liang Quan Li, Daniel L. Klayman, Clifford F. George, and Judith L. Flippen-Anderson pp 2610 - 2614; DOI: 10.1021/jm00171a041 |
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Synthesis and antineoplastic properties of ether-linked thioglycolipids Pedro N. Guivisdalsky, Robert Bittman, Zigrida Smith, Merle L. Blank, Fred Snyder, Sandra Howard, and Hassan Salari pp 2614 - 2621; DOI: 10.1021/jm00171a042 |
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Synthesis and in vitro LTD4 antagonist activity of bicyclic and monocyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides Victor G. Matassa, Frederick J. Brown, Peter R. Bernstein, Howard S. Shapiro, Thomas P. Maduskuie Jr., Laura A. Cronk, Edward P. Vacek, Ying K. Yee, David W. Snyder, and et al. pp 2621 - 2629; DOI: 10.1021/jm00171a043 |
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Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines Karnail S. Atwal, George C. Rovnyak, S. David Kimball, David M. Floyd, Suzanne Moreland, Brian N. Swanson, Jack Z. Gougoutas, Joseph Schwartz, Kaye M. Smillie, and Mary F. Malley pp 2629 - 2635; DOI: 10.1021/jm00171a044 |
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1-(Aminoalkyl)-2-phenylindoles as novel pure estrogen antagonists Erwin Von Angerer, Norbert Knebel, Mario Kager, and Bernhard Ganss pp 2635 - 2640; DOI: 10.1021/jm00171a045 |
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Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity Ian T. Forbes, Christopher N. Johnson, Graham E. Jones, Julia Loudon, Jane M. Nicholass, Mervyn Thompson, and Neil Upton pp 2640 - 2645; DOI: 10.1021/jm00171a046 |
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Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships Vittoria Colotta, Lucia Cecchi, Fabrizio Melani, Guido Filacchioni, Claudia Martini, Gino Giannaccini, and Antonio Lucacchini pp 2646 - 2651; DOI: 10.1021/jm00171a047 |
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Heterosubstituted anthracene-9,10-dione analogs. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4,9-diones A. Paul Krapcho, Mary E. Petry, and Miles P. Hacker pp 2651 - 2655; DOI: 10.1021/jm00171a048 |
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NMR studies of configuration and tautomeric equilibria in nitroacridine antitumor agents Maruta Boyd and William A. Denny pp 2656 - 2659; DOI: 10.1021/jm00171a049 |
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Antitumor agents. 113. New 4.beta.-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II Zhe Qing Wang, Yao Haur Kuo, Dora Schnur, J. Phillip Bowen, Su Ying Liu, Fu Sheng Han, Jang Yang Chang, Yung Chi Cheng, and Kuo Hsiung Lee pp 2660 - 2666; DOI: 10.1021/jm00171a050 |
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Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans Valerie A. Ashwood, Frederick Cassidy, Martin C. Coldwell, John M. Evans, Thomas C. Hamilton, David R. Howlett, Duncan M. Smith, and Geoffrey Stemp pp 2667 - 2672; DOI: 10.1021/jm00171a051 |
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Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analog, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives Charles A. Laughton, Robert McKenna, Stephen Neidle, Michael Jarman, Ray McCague, and Martin G. Rowlands pp 2673 - 2679; DOI: 10.1021/jm00171a052 |
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Affinity of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for .alpha.-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled .alpha.2-adrenoceptor vs. the [3H]yohimbime-labeled site [Erratum to document cited in CA112(7):55713w Robin D. Clark, Jacob Berger, Pushkal Garg, Klaus K. Weinhardt, Michael Spedding, Andrew T. Kilpatrick, Christine M. Brown, and Alison C. MacKinnon pp 2679 - 2679; DOI: 10.1021/jm00171a053 |
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Cholecystokinin-A receptor ligands based on the .kappa.-opioid agonist tifluadom [Erratum to document cited in CA112(5):30228d] Mark G. Bock, Robert M. DiPardo, Ben E. Evans, Kenneth E. Rittle, Willie L. Whitter, Daniel F. Veber, Roger M. Freidinger, Raymond S. L. Chang, T. B. Chen, and Victor J. Lotti pp 2679 - 2679; DOI: 10.1021/jm00171a054 |
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Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups [Erratum to document cited in CA112(5):35753f] C. Jones, Winter David, A Mark, Kenneth S. Hirsch, Nancy Stamm, Harold M. Taylor, Howard E. Holden, James D. Davenport, Eriks V. Krumkalns, and Robert G. Suhr pp 2679 - 2679; DOI: 10.1021/jm00171a055 |
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Book Reviews pp 2680 - 2684; DOI: 10.1021/jm00171a600 |
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Antiatherosclerotic agents. A structurally novel bivalent inhibitor of AcylCoA:cholesterol O-acyltransferase with systemic activity Ronald B. Gammill, Frank P. Bell, Larry T. Bell, Sharon N. Bisaha, and Grace J. Wilson pp 2685 - 2687; DOI: 10.1021/jm00172a001 |
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Structure-based, C2 symmetric inhibitors of HIV protease Dale J. Kempf, Daniel W. Norbeck, LynnMarie Codacovi, Xiu Chun Wang, William E. Kohlbrenner, Norman E. Wideburg, Deborah A. Paul, Mark F. Knigge, Sudthida Vasavanonda, and et al. pp 2687 - 2689; DOI: 10.1021/jm00172a002 |
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Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors Leslie J. Street, Raymond Baker, Tracey Book, Clare O. Kneen, Angus M. MacLeod, Kevin J. Merchant, Graham A. Showell, John Saunders, Richard H. Herbert, and et al. pp 2690 - 2697; DOI: 10.1021/jm00172a003 |
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Substituted 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones as potential antiinflammatory agents Pauline C. Ting, James J. Kaminski, Margaret H. Sherlock, Wing C. Tom, Joe F. Lee, Robert W. Bryant, Arthur S. Watnick, and Andrew T. McPhail pp 2697 - 2706; DOI: 10.1021/jm00172a004 |
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Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction Kinji Iizuka, Tetsuhide Kamijo, Hiromu Harada, Kenji Akahane, Tetsuhiro Kubota, Hideaki Umeyama, Toshimasa Ishida, and Yoshiaki Kiso pp 2707 - 2714; DOI: 10.1021/jm00172a005 |
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Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists Terry Rosen, Arthur A. Nagel, James P. Rizzi, Jeffrey L. Ives, June B. Daffeh, Alan H. Ganong, Karen Guarino, James Heym, Stafford McLean, and et al. pp 2715 - 2720; DOI: 10.1021/jm00172a006 |
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An initial three-component pharmacophore for specific serotonin-3 receptor ligands James P. Rizzi, Arthur A. Nagel, Terry Rosen, Stafford McLean, and Thomas Seeger pp 2721 - 2725; DOI: 10.1021/jm00172a007 |
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Torsionally and hydrophobically modified 2,3-diarylindenes as estrogen-receptor ligands Gregory M. Anstead, Chad S. Peterson, Kevin G. Pinney, Scott R. Wilson, and John A. Katzenellenbogen pp 2726 - 2734; DOI: 10.1021/jm00172a008 |
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Synthesis of acyclic and dehydroaspartic acid analogs of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated .alpha.-linked acidic dipeptidase (NAALA dipeptidase) Nalin Subasinghe, Marvin Schulte, Michael Y. M. Chan, Robert J. Roon, James F. Koerner, and Rodney L. Johnson pp 2734 - 2744; DOI: 10.1021/jm00172a009 |
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Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors J. L. Malleron, G. Roussel, G. Gueremy, G. Ponsinet, J. L. Robin, B. Terlain, and J. M. Tissieres pp 2744 - 2749; DOI: 10.1021/jm00172a010 |
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Direct C-glycosylation of guanine analogs: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides Nabih S. Girgis, Maged A. Michael, Donald F. Smee, Hassan A. Alaghamandan, Roland K. Robins, and Howard B. Cottam pp 2750 - 2755; DOI: 10.1021/jm00172a011 |
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Antimicrobial properties of N3-(iodoacetyl)-L-2,3-diaminopropanoic acid-peptide conjugates Ryszard Andruszkiewicz, Henryk Chmara, Slawomir Milewski, Teresa Zieniawa, and Edward Borowski pp 2755 - 2759; DOI: 10.1021/jm00172a012 |
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4-Heterocyclyloxy-2H-1-benzopyran potassium channel activators Rolf Bergmann, Volker Eiermann, and Rolf Gericke pp 2759 - 2767; DOI: 10.1021/jm00172a013 |
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Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates Craig L. Hill, Mark S. Weeks, and Raymond F. Schinazi pp 2767 - 2772; DOI: 10.1021/jm00172a014 |
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2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents John M. Kane, Bruce M. Baron, Mark W. Dudley, Stephen M. Sorensen, Michael A. Staeger, and Francis P. Miller pp 2772 - 2777; DOI: 10.1021/jm00172a015 |
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Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region Richard A. Glennon, Chandra Chaurasia, and Milt Titeler pp 2777 - 2784; DOI: 10.1021/jm00172a016 |
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Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin P. W. Collins, A. F. Gasiecki, W. E. Perkins, G. W. Gullikson, R. G. Bianchi, S. W. Kramer, J. S. Ng, E. E. Yonan, L. Swenton, and et al. pp 2784 - 2793; DOI: 10.1021/jm00172a017 |
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Pyrroloisoquinoline antidepressants. 3. A focus on serotonin Bruce E. Maryanoff, Jeffry L. Vaught, Richard P. Shank, David F. McComsey, Michael J. Costanzo, and Samuel O. Nortey pp 2793 - 2797; DOI: 10.1021/jm00172a018 |
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Benzophenone dicarboxylic acid antagonists of leukotriene B4. 1. Structure-activity relationships of the benzophenone nucleus D. Mark Gapinski, Barbara E. Mallett, Larry L. Froelich, and William T. Jackson pp 2798 - 2807; DOI: 10.1021/jm00172a019 |
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Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain D. Mark Gapinski, Barbara E. Mallett, Larry L. Froelich, and William T. Jackson pp 2807 - 2813; DOI: 10.1021/jm00172a020 |
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A Free-Wilson/Fujita-Ban analysis and prediction of the analgesic potency of some 3-hydroxy- and 3-methoxy-N-alkylmorphinan-6-one opioids Zurisaddai Hernandez-Gallegos and Pedro A. Lehmann pp 2813 - 2817; DOI: 10.1021/jm00172a021 |
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Imidazodiazepinediones: a new class of adenosine receptor antagonists John W. Daly, Izumi Hide, and Peter K. Bridson pp 2818 - 2821; DOI: 10.1021/jm00172a022 |
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7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists Christa E. Mueller, Izumi Hide, John W. Daly, Klaus Rothenhaeusler, and Kurt Eger pp 2822 - 2828; DOI: 10.1021/jm00172a023 |
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The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency Robert A. Galemmo Jr., William H. Johnson Jr., Keith S. Learn, Thomas D. Y. Lee, Fu Chih Huang, Henry F. Campbell, Raymond Youssefyeh, Susan V. O'Rourke, Glenn Schuessler, and et al. pp 2828 - 2841; DOI: 10.1021/jm00172a024 |
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Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist J. Y. Gauthier, T. Jones, E. Champion, L. Charette, R. Dehaven, A. W. Ford-Hutchinson, K. Hoogsteen, A. Lord, P. Masson, and et al. pp 2841 - 2845; DOI: 10.1021/jm00172a025 |
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Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogs of trichostatin A S. Massa, Marino Artico, F. Corelli, A. Mai, R. Di Santo, S. Cortes, M. E. Marongiu, A. Pani, and P. La Colla pp 2845 - 2849; DOI: 10.1021/jm00172a026 |
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Synthesis and antitumor activity of 2-.beta.-D-ribofuranosyloxazole-4-carboxamide (oxazofurin) Palmarisa Franchetti, Gloria Cristalli, Mario Grifantini, Loredana Cappellacci, Sauro Vittori, and Giuseppe Nocentini pp 2849 - 2852; DOI: 10.1021/jm00172a027 |
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8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity Wieslaw M. Cholody, Sante Martelli, and Jerzy Konopa pp 2852 - 2856; DOI: 10.1021/jm00172a028 |
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Propenyl carboxamide derivatives as antagonists of platelet-activating factor Robert W. Guthrie, Gerald L. Kaplan, Francis A. Mennona, Jefferson W. Tilley, Richard W. Kierstead, Margaret O'Donnell, Herman Crowley, Bohdan Yaremko, and Ann F. Welton pp 2856 - 2864; DOI: 10.1021/jm00172a029 |
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Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans Anna Arnoldi, Alberto Bonsignori, Piero Melloni, Lucio Merlini, Maria Luisa Quadri, Alessandro C. Rossi, and Mariella Valsecchi pp 2865 - 2869; DOI: 10.1021/jm00172a030 |
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Nonsteroidal cardiotonics. 3. New 4,5-dihydro-6-(1H-indol-5-yl)pyridazin-3(2H)-ones and related compounds with positive inotropic activities Alfred Mertens, Walter Gunar Friebe, Bernd Mueller-Beckmann, Wolfgang Kampe, Lothar Kling, and Wolfgang Von der Saal pp 2870 - 2875; DOI: 10.1021/jm00172a031 |
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Synthesis and pharmacological evaluation of a series of new 1,4-disubstituted 3-methyl-piperidine analgesics Nhora Lalinde, John Moliterni, Denny Wright, H. Kenneth Spencer, Michael H. Ossipov, Theodore C. Spaulding, and Frieda G. Rudo pp 2876 - 2882; DOI: 10.1021/jm00172a032 |
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Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity Randall Lis, Thomas K. Morgan, Anthony J. Marisca, Robert P. Gomez, Joan M. Lind, David D. Davey, Gary B. Phillips, and Mark E. Sullivan pp 2883 - 2891; DOI: 10.1021/jm00172a033 |
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(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors John Ellingboe, Thomas Alessi, Jane Millen, Janet Sredy, Andrew King, Candace Prusiewicz, Frieda Guzzo, Donna VanEngen, and Jehan Bagli pp 2892 - 2899; DOI: 10.1021/jm00172a034 |
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2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity John P. Yardley, G. E. Morris Husbands, Gary Stack, Jacqueline Butch, James Bicksler, John A. Moyer, Eric A. Muth, Terrance Andree, Horace Fletcher, III, and et al. pp 2899 - 2905; DOI: 10.1021/jm00172a035 |
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Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids Robin D. Allan, Jane R. Hanrahan, Trevor W. Hambley, Graham A. R. Johnston, Kenneth N. Mewett, and Ann D. Mitrovic pp 2905 - 2915; DOI: 10.1021/jm00172a036 |
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New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure activity relationships and pharmacological evaluation Sheryl J. Hays, Christopher F. Bigge, Perry M. Novak, James T. Drummond, Thomas P. Bobovski, Michael J. Rice, Graham Johnson, Laura J. Brahce, and Linda L. Coughenour pp 2916 - 2924; DOI: 10.1021/jm00172a037 |
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Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin Anette M. Johansson, Karin Fredriksson, Uli Hacksell, Cor J. Grol, Kjell Svensson, Arvid Carlsson, and Staffan Sundell pp 2925 - 2929; DOI: 10.1021/jm00172a038 |
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Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7-(4-hydroxypiperazin-1-yl)quinolones Toshio Uno, Hirosato Kondo, Yoshimasa Inoue, Yoshihiro Kawahata, Mikio Sotomura, Koji Iuchi, and Goro Tsukamoto pp 2929 - 2932; DOI: 10.1021/jm00172a039 |
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Mechanism and inhibition of cytochrome P-450 aromatase Philip A. Cole and Cecil H. Robinson pp 2933 - 2942; DOI: 10.1021/jm00173a001 |
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Benzotriazinones as virtual-ring mimics of o-methoxybenzamides: novel and potent 5-HT3 receptor antagonists Frank D. King, Steven Dabbs, Jose Bermudez, and Gareth J. Sanger pp 2942 - 2944; DOI: 10.1021/jm00173a002 |
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3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex Francesco G. Salituro, Boyd L. Harrison, Bruce M. Baron, Philip L. Nyce, Kenneth T. Stewart, and Ian A. McDonald pp 2944 - 2946; DOI: 10.1021/jm00173a003 |
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Structure-activity relationships in 1,4-benzodioxan related compounds. 3. 3-Phenyl analogs of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxan (WB 4101) as highly selective .alpha.1-adrenoreceptor antagonists Wilma Quaglia, Maria Pigini, Mario Giannella, and Carlo Melchiorre pp 2946 - 2948; DOI: 10.1021/jm00173a004 |
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(1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist Michael P. DeNinno, Robert Schoenleber, Karen E. Asin, Robert MacKenzie, and John W. Kebabian pp 2948 - 2950; DOI: 10.1021/jm00173a005 |
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Development of CCK-tetrapeptide analogs as potent and selective CCK-A receptor agonists Kazumi Shiosaki, Chun Wel Lin, Hana Kopecka, Richard Craig, Frank L. Wagenaar, Bruce Bianchi, Thomas Miller, David Witte, and Alex M. Nadzan pp 2950 - 2952; DOI: 10.1021/jm00173a006 |
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Phosphorus-containing inhibitors of HMG-CoA reductase. I. 4-[(2-Arylethyl)hydroxyphosphinyl]-3-hydroxybutanoic acids: a new class of cell selective inhibitors of cholesterol biosynthesis Donald S. Karanewsky, Michael C. Badia, Carl P. Ciosek, Jeffrey A. Robl, Michael J. Sofia, Ligaya M. Simpkins, Barbara DeLange, Thomas W. Harrity, Scott A. Biller, and Eric M. Gordon pp 2952 - 2956; DOI: 10.1021/jm00173a007 |
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Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses Heechung Yang, Jack Henkin, Ki H. Kim, and Jonathan Greer pp 2956 - 2961; DOI: 10.1021/jm00173a008 |
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(R)-4-Oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex Jeffrey P. Whitten, Bruce M. Baron, Daniel Muench, Francis Miller, H. Steven White, and Ian A. McDonald pp 2961 - 2963; DOI: 10.1021/jm00173a009 |
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Antiarthritic and supressor cell inducing activity of azaspiranes: structure-function relationships of a novel class of immunomodulatory agents Alison M. Badger, David A. Schwartz, Donald H. Picker, James W. Dorman, Fontaine C. Bradley, Elaine N. Cheeseman, Michael J. DiMartino, Nabil Hanna, and Christopher K. Mirabelli pp 2963 - 2970; DOI: 10.1021/jm00173a010 |
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Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of [.beta.-(aroylamino)ethyl]piperazines and -piperidines and [2-[(arylamino)carbonyl]ethyl]piperazines, -piperidines, -pyrazinopyridoindoles, and -pyrazinoisoquinolines. A new class of potent H1 antagonists Mridula Saxena, Shiv K. Agarwal, G. K. Patnaik, and Anil K. Saxena pp 2970 - 2976; DOI: 10.1021/jm00173a011 |
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Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds Juergen Engel, Ilona Fleischhauer, Vladimir Jakovlev, Axel Kleemann, Bernhard Kutscher, Bernd Nickel, Horst Rauer, Ulrich Werner, Istvan Szelenyi, and et al. pp 2976 - 2981; DOI: 10.1021/jm00173a012 |
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Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors S. Y. Sit, R. A. Parker, I. Motoc, W. Han, N. Balasubramanian, J. D. Catt, P. J. Brown, W. E. Harte, M. D. Thompson, and J. J. Wright pp 2982 - 2999; DOI: 10.1021/jm00173a013 |
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Structural, conformational, and theoretical binding studies of antitumor antibiotic porfiromycin (N-methylmitomycin C), a covalent binder of DNA, by x-ray, NMR, and molecular mechanics S. K. Arora, M. B. Cox, and P. Arjunan pp 3000 - 3008; DOI: 10.1021/jm00173a014 |
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DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine Brian D. Palmer, Ho H. Lee, Paul Johnson, Bruce C. Baguley, Geoffrey Wickham, Laurence P. G. Wakelin, W. David McFadyen, and William A. Denny pp 3008 - 3014; DOI: 10.1021/jm00173a015 |
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DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain Kisione K. Valu, Trudi A. Gourdie, Theodore J. Boritzki, G. Lance Gravatt, Bruce C. Baguley, William R. Wilson, Laurence P. G. Wakelin, Paul D. Woodgate, and William A. Denny pp 3014 - 3019; DOI: 10.1021/jm00173a016 |
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Synthesis, in vitro binding profile, and CNS penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole Terry Rosen, Thomas F. Seeger, Stafford McLean, Arthur A. Nagel, Jefferey L. Ives, Karen J. Guarino, Dianne Bryce, Jerome Furman, Robert W. Roth, and et al. pp 3020 - 3023; DOI: 10.1021/jm00173a017 |
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Variation in the aromatic ring of cromakalim: antihypertensive activity of pyranopyridines and 6-alkyl-2H-1-benzopyrans Gordon Burrell, Frederick Cassidy, John M. Evans, Diane Lightowler, and Geoffrey Stemp pp 3023 - 3027; DOI: 10.1021/jm00173a018 |
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Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis Derek R. Buckle, Jonathon R. S. Arch, Ashley E. Fenwick, Catherine S. V. Houge-Frydrych, Ivan L. Pinto, David G. Smith, Stephen G. Taylor, and John M. Tedder pp 3028 - 3034; DOI: 10.1021/jm00173a019 |
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Further insights into the oxidation chemistry and biochemistry of the serotonergic neurotoxin 5,6-dihydroxytryptamine Satendra Singh and Glenn Dryhurst pp 3035 - 3044; DOI: 10.1021/jm00173a020 |
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Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates Carroll Temple and Gregory A. Rener pp 3044 - 3050; DOI: 10.1021/jm00173a021 |
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Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid Raymond McCague, Martin G. Rowlands, S. Elaine Barrie, and John Houghton pp 3050 - 3055; DOI: 10.1021/jm00173a022 |
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Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity Charles A. Laughton and Stephen Neidle pp 3055 - 3060; DOI: 10.1021/jm00173a023 |
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Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C-2 position Leslie R. Hughes, Ann L. Jackman, John Oldfield, Rodney C. Smith, Kenneth D. Burrows, Peter R. Marsham, Joel A. M. Bishop, Terence R. Jones, Brigid M. O'Connor, and A. Hilary Calvert pp 3060 - 3067; DOI: 10.1021/jm00173a024 |
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Quinazoline antifolate thymidylate synthase inhibitors: 2'-Fluoro-N10-propargyl-5,8,-dideazafolic acid and derivatives with modifications in the C-2 position Ann L. Jackman, Peter R. Marsham, Timothy J. Thornton, Joel A. M. Bishop, Brigid M. O'Connor, Leslie R. Hughes, A. Hilary Calvert, and Terence R. Jones pp 3067 - 3071; DOI: 10.1021/jm00173a025 |
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Quinazoline-antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series Peter R. Marsham, Ann L. Jackman, John Oldfield, Leslie R. Hughes, Timothy J. Thornton, Graham M. F. Bisset, Brigid M. O'Connor, Joel A. M. Bishop, and A. Hilary Calvert pp 3072 - 3078; DOI: 10.1021/jm00173a026 |
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Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin Maurice Manning, Stoytcho Stoev, Aleksander Kolodziejczyk, Wieslaw A. Klis, Marian Kruszynski, Aleksandra Misicka, Aleksandra Olma, Nga Ching Wo, and Wilbur H. Sawyer pp 3079 - 3086; DOI: 10.1021/jm00173a027 |
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Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine Herbert A. Kirst, Julie A. Wind, James P. Leeds, Kevin E. Willard, Manuel Debono, Rosanne Bonjouklian, James M. Greene, Kevin A. Sullivan, Jonathan W. Paschal, and et al. pp 3086 - 3094; DOI: 10.1021/jm00173a028 |
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Synthesis and antiarrhythmic activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines Toshiaki Kumazawa, Hiroyuki Harakawa, Hiroyuki Obase, Yoshimasa Oiji, Masaaki Nito, Kazuhiro Kubo, Akio Ishii, Shinji Tomioka, and Yoshiyuki Yamada pp 3095 - 3100; DOI: 10.1021/jm00173a029 |
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Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity .sigma. receptor ligands. Identification of a new class of highly potent and selective .sigma. receptor probes Brian R. De Costa, Wayne D. Bowen, Andrew Thurkauf, Daniel T. Finn, Sondra Vazirani, Richard B. Rothman, Linda Band, Patricia C. Contreras, Nancy M. Gray, and et al. pp 3100 - 3110; DOI: 10.1021/jm00173a030 |
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Potent anticonflict activity and lessening of memory impairment with a series of novel [1]benzothieno[2,3-c]pyridines and 1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridines Hiromu Kawakubo, Katuya Okazaki, Tadasi Nagatani, Katuyuki Takao, Shinichi Hasimoto, and Taisuke Sugihara pp 3110 - 3116; DOI: 10.1021/jm00173a031 |
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Synthesis and biological activity of an acyclic analog of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid [Erratum to document cited in CA112(7):56616d] James L. Kelley, Ed W. McLean, Naomi K. Cohn, Mark P. Edelstein, David S. Duch, Gary K. Smith, Mary H. Hanlon, and Robert Ferone pp 3116 - 3116; DOI: 10.1021/jm00173a032 |
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Book Reviews pp 3117 - 3118; DOI: 10.1021/jm00173a600 |
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Evidence for nitroxyl in the catalase-mediated bioactivation of the alcohol deterrent agent cyanamide H. T. Nagasawa, E. G. DeMaster, B. Redfern, F. N. Shirota, and D. J. W. Goon pp 3120 - 3122; DOI: 10.1021/jm00174a001 |
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Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist John L. Neumeyer, Yigong Gao, Nora S. Kula, and Ross J. Baldessarini pp 3122 - 3124; DOI: 10.1021/jm00174a002 |
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Expedient synthesis and biochemical properties of an [125I]-labeled analogue of glyburide, a radioligand for ATP-inhibited potassium channels David W. Robertson, Douglas A. Schober, Joseph H. Krushinski, Dale E. Mais, Dennis C. Thompson, and Donald R. Gehlert pp 3124 - 3126; DOI: 10.1021/jm00174a003 |
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A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors Norton P. Peet, Nelsen L. Lentz, Elaine C. Meng, Mark W. Dudley, Ann Marie L. Ogden, David A. Demeter, Herschel J. R. Weintraub, and Philippe Bey pp 3127 - 3130; DOI: 10.1021/jm00174a004 |
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4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate (NMDA) receptor complex Boyd L. Harrison, Bruce M. Baron, Diane M. Cousino, and Ian A. McDonald pp 3130 - 3132; DOI: 10.1021/jm00174a005 |
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Chiral modifications of dolastatin 10: the potent cytostatic peptide (19aR)-isodolastatin 10 George R. Pettit, Sheo Bux Singh, Fiona Hogan, and Douglas D. Burkett pp 3132 - 3133; DOI: 10.1021/jm00174a006 |
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Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analog: synthesis and monoamine oxidase catalyzed bioactivation S. Mbera Ngale Efange, R. H. Michelson, R. P. Remmel, R. J. Boudreau, A. K. Dutta, and A. Freshler pp 3133 - 3138; DOI: 10.1021/jm00174a007 |
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Hemoglobin S antigelation agents based on 5-bromotryptophan with potential for sickle cell anemia Philomen Z. De Croos, Puckprink Sangdee, Brenda L. Stockwell, Leela Kar, Emmanuel B. Thompson, Michael E. Johnson, and Bruce L. Currie pp 3138 - 3142; DOI: 10.1021/jm00174a008 |
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11.beta.-Methoxy-, 11.beta.-ethyl, and 17.alpha.-ethynyl-substituted 16.alpha.-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity Martin G. Pomper, Henry VanBrocklin, Andrea M. Thieme, Ralph D. Thomas, Dale O. Kiesewetter, Kathryn E. Carlson, Carla J. Mathias, Michael J. Welch, and John A. Katzenellenbogen pp 3143 - 3155; DOI: 10.1021/jm00174a009 |
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Synthesis and estrogen receptor binding of novel 11.beta.-substituted estra-1,3,5(10)-triene-3,17.beta.-diols Robert N. Hanson, Elio Napolitano, Rita Fiaschi, and Kay D. Onan pp 3155 - 3160; DOI: 10.1021/jm00174a010 |
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Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections Steven H. Krawczyk, Martha Bernier-Rodriguez, M. Reza Nassiri, Earl R. Kern, Linda L. Wotring, John C. Drach, and Leroy B. Townsend pp 3160 - 3169; DOI: 10.1021/jm00174a011 |
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Synthesis and cytotoxicity studies of 8-amino-6-methyl-2-.beta.-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene (7-Aza-TCN) and the corresponding 2'-deoxy- and arabinonucleoside analogues Andrew M. Kawasaki, Linda L. Wotring, and Leroy B. Townsend pp 3170 - 3176; DOI: 10.1021/jm00174a012 |
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Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxamide, a useful radioligand for 5HT3 receptors David W. Robertson, William Bloomquist, Marlene L. Cohen, Leroy R. Reid, Kathryn Schenck, and David T. Wong pp 3176 - 3181; DOI: 10.1021/jm00174a013 |
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Resolved pyrrolidine, piperidine, and perhydroazepine analogs of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide J. R. Michael Lundkvist, Hugo M. Vargas, Patrizia Caldirola, Bjoern Ringdahl, and Uli Hacksell pp 3182 - 3189; DOI: 10.1021/jm00174a014 |
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Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogs of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5) Eugene J. Trybulski, Richard H. Kramss, Richard M. Mangano, and Andrew Rusinko pp 3190 - 3198; DOI: 10.1021/jm00174a015 |
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Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists R. Gonzalez-Muniz, F. Bergeron, I. Marseigne, C. Durieux, and Bernard P. Roques pp 3199 - 3204; DOI: 10.1021/jm00174a016 |
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4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists Carlos E. Sunkel, Miguel Fau de Casa-Juana, Luis Santos, M. Mar Gomez, Mercedes Villarroya, M. Antonia Gonzalez-Morales, Jaime G. Priego, and M. Pilar Ortega pp 3205 - 3210; DOI: 10.1021/jm00174a017 |
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Structure-activity relationship of antiestrogens. Studies on 2,3-diaryl-1-benzopyrans Ashraf Saeed, Arun P. Sharma, Neelam Durani, Raka Jain, Susheel Durani, and Randhir S. Kapil pp 3210 - 3216; DOI: 10.1021/jm00174a018 |
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Structure-activity relationship of antiestrogens. Effect of the side chain and its position on activity of 2,3-diaryl-2H-1-benzopyrans Arun P. Sharma, Ashraf Saeed, Susheel Durani, and Randhir S. Kapil pp 3216 - 3222; DOI: 10.1021/jm00174a019 |
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Structure-activity relationship of antiestrogens. Phenolic analogs of 2,3-diaryl-2H-1-benzopyrans Arun P. Sharma, Ashraf Saeed, Susheel Durani, and Randhir S. Kapil pp 3222 - 3229; DOI: 10.1021/jm00174a020 |
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Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept [Erratum to document cited in CA112(25):235659s] P. S. Portoghese, M. Sultana, and A. E. Takemori pp 3229 - 3229; DOI: 10.1021/jm00174a021 |
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Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties [Erratum to document cited in CA112(21):198106m] Manfred Reiffen, Wolfgang Eberlein, Peter Mueller, Manfred Psiorz, Klaus Noll, Joachim Heider, Christian Lillie, Walter Kobinger, and Peter Luger pp 3229 - 3229; DOI: 10.1021/jm00174a022 |
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Editorial - Expediting Publication of Communications to the Editor P. S. Portoghese pp 3119 - 3119; DOI: 10.1021/jm00174a600 |